FMOC-D-GLU(OALL)-OH

Base Information

• Chemical Name: FMOC-D-GLU(OALL)-OH
• CAS No.: 204251-33-2
• Molecular Formula: C23H23 N O6
• Molecular Weight: 409.439
• Mol file: 204251-33-2.mol

Synonyms:D-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(2-propenyl)ester (9CI)

Chemical Property of FMOC-D-GLU(OALL)-OH

Chemical Property:

• PSA: 101.93000
• LogP: 3.87860
• Storage Temp.: Store at 0°C

Purity/Quality:

≥98%, ^*data from raw suppliers

Fmoc-D-glutamic acid γ-allyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-GLU(OALL)-OH

There total 1 articles about FMOC-D-GLU(OALL)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + γ-allyl (2R)-glutamate hydrochloride → γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate (204251-33-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1039/b100401h

Reference yield: 11.2%

2-azidoacetic acid (18523-48-3) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-L-Lys(iPr,Boc)-OH (201003-48-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine (138774-94-4,186320-03-6) + Fmoc-Lys(ivDde)-OH (204777-78-6) + Fmoc-D-arginine (130752-32-8) + γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate (204251-33-2) → C85H122N22O21

Guidance literature:

Fmoc-Lys(ivDde)-OH;

With N-Acetylimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-azidoacetic acid; N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-L-Lys(iPr,Boc)-OH; N-Fmoc L-Phe; Fmoc-Glu(OtBu)-OH; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine; Fmoc-D-arginine; γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate; Further stages;

Reference yield: 10.5%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0) + Fmoc-L-Lys(iPr,Boc)-OH (201003-48-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine (138774-94-4,186320-03-6) + Fmoc-Lys(ivDde)-OH (204777-78-6) + 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid (137076-54-1) + Fmoc-D-arginine (130752-32-8) + γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate (204251-33-2) → C120H187N25O29

Guidance literature:

Fmoc-Lys(ivDde)-OH;

With N-Acetylimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-(fluoren-9-ylmethoxycarbonyl)glycine; 1,18-octadecanedioic acid mono-tert-butyl ester; Fmoc-L-Lys(iPr,Boc)-OH; N-Fmoc L-Phe; Fmoc-Glu(OtBu)-OH; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine; Fmoc-Lys(ivDde)-OH; 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid; Fmoc-D-arginine; γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate; Further stages;

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate ester

cyclo[-β-Ala-(2R)-Glu-α-OMe-γ-(2S)-Pro-(2R)-Asp-β-(2S)-Phe-]

(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

cyclo{-(2S)-Phe-[(2R)-α-4-benzylpiperidinyl-Asp]-(2R)-α-OMe-Glu-γ-(2S)-Pro-β-(2R)-Asp-}

Refernces