Ravuconazole

Base Information Edit

Chemical Name:Ravuconazole
CAS No.:170864-29-6
Molecular Formula:C₂₂H₁₇F₂N₅OS
Molecular Weight:437.473
Hs Code.:
Mol file:170864-29-6.mol

Synonyms:(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid;(2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-buta n-2-ol;N-(tert-Butoxycarbonyl)-(2R,3R,2'S)-dolaproine;(1R,2R)-4-[2-[2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl]-benzonitrile;(2R,3R,4S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxy-2-methyl-propanoic acid;(2R,3R)-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-3-methoxy-2-methylpropanoic acid;N-Boc-dolaproline;3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;(2R,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxy-2-methylpropanoic acid;

Suppliers and Price of Ravuconazole

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 8 raw suppliers

Chemical Property of Ravuconazole Edit

Chemical Property:

Melting Point:148-151°C
PSA：115.86000
LogP:4.24298
Storage Temp.:-20?C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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MSDS Files:: SDS file from LookChem

Useful:

Description Ravuconazole belongs to a group of ‘‘second generation’’ triazoles; developed to overcome limitations, drug resistance, and drug interactions of the earlier triazoles. Formerly BMS-207147 and ER-30346, it was discovered by Eisai Co. Ltd. in Japan, developed by Bristol-Myers Squibb, and is now held again by Eisai. It is structurally related to fluconazole and voriconazole but, like isavuconazole, has a long half-life.
Uses Ergosterol biosynthesis inhibitor. Antifungal.
Drug interactions Ravuconazole may have a lower potential for drug interactions as it is a less-potent inhibitor of CYP3A4 than voriconazole; however, no information is available about interaction with other liver cytochrome enzymes such as CYP2C9 or 2C19. One clinical trial of ravuconazole in subjects with oral candidiasis and HIV found that rifampicin reduced ravuconazole levels by over 50%.

Technology Process of Ravuconazole

There total 1 articles about Ravuconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: