5-METHOXYPYRAZINECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-METHOXYPYRAZINECARBOXYLIC ACID METHYL ESTER
• CAS No.: 38789-75-2
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 2933990090
• Mol file: 38789-75-2.mol

Synonyms:Pyrazinecarboxylicacid, 5-methoxy-, methyl ester (9CI)

Chemical Property of 5-METHOXYPYRAZINECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Boiling Point: 259.9oC at 760 mmHg
• PKA: -2.09±0.10(Predicted)
• Flash Point: 111oC
• PSA: 51.13000
• Density: 1.22g/cm3
• LogP: -0.04200
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl5-methoxypyrazine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-METHOXYPYRAZINECARBOXYLIC ACID METHYL ESTER

There total 8 articles about 5-METHOXYPYRAZINECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

sodium methylate (124-41-4) + methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → methyl 5-methoxypyrazine-2-carboxylate (38789-75-2)

Guidance literature:

In methanol; at 60 ℃; for 18h;

Reference yield: 79.0%

methanol (67-56-1) + methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → methyl 5-methoxypyrazine-2-carboxylate (38789-75-2)

Guidance literature:

With sodium methylate; at 90 ℃; for 0.25h; Inert atmosphere;

Reference yield: 62.0%

methanol (67-56-1) + 5-chloropyrazinoic acid (36070-80-1) → methyl 5-chloropyrazine-2-carboxylate (33332-25-1) + methyl 5-methoxypyrazine-2-carboxylate (38789-75-2)

Guidance literature:

With hydrogenchloride; for 1h; Yields of byproduct given; Heating;

upstream raw materials:

methanol

5-chloropyrazinoic acid

2-Hydroxy-5-(2'-furyl)pyrazine

2-chloro-5-furan-2-yl-pyrazine

Downstream raw materials:

(5-methoxypyrazin-2-yl)methanol

5-methoxypyrazine-2-carbaldehyde

2-(chloromethyl)-5-methoxypyrazine

Refernces

• 1、 Kuramoto, Kazuyuki,Sawada, Yuki,Yamada, Tomohiro,Nagashima, Takeyuki,Ohnuki, Kei,Shin, Takashi. "Novel indirect AMP-activated protein kinase activators: Identification of a second-generation clinical candidate with improved physicochemical properties and reduced hERG inhibitory activity". . p. 452 - 465. Retrieved 2020/09/09.
• 2、 -. "1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS". Paragraph 0556-0557. . Retrieved 2019/07/10.