(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride

Base Information

• Chemical Name: (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride
• CAS No.: 93601-86-6
• Molecular Formula: C14H21NO^.HCl
• Molecular Weight: 255.788
• Hs Code.: 2932999099
• Mol file: 93601-86-6.mol

Synonyms:(2S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminhydrochlorid(1:1);

Chemical Property of (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride

Chemical Property:

• Vapor Pressure: 0-0Pa at 20-25℃
• PSA: 21.26000
• Density: 1.19g/cm3 at 20℃
• LogP: 3.74500
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO, Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride

There total 14 articles about (S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3aS,9bR)-6-methoxy-3-propyl-3,3a,4,5-tetrahydronaphtho[2,1-d]oxazol-2(9bH)-one (1256261-00-3) → (S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93601-86-6)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; under 1810.07 Torr;

DOI:10.1021/ol1022239

Reference yield: 96.0%

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride (101403-24-1,3899-07-8) → (S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93601-86-6)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/adsc.201701198

Reference yield: 94.0%

(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate (1352917-66-8) → (S)-(-)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride (93601-86-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 65 ℃; for 0.25h;

upstream raw materials:

(3aS,9bR)-6-methoxy-3-propyl-3,3a,4,5-tetrahydronaphtho[2,1-d]oxazol-2(9bH)-one

SKF 87967 hydrochloride

2-(N-propylamino)-5-methoxytetraline

(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Downstream raw materials:

(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide

(2S)-5-hydroxy-2-(di-n-propylamino)tetralin

rotigotine

rotigotine hydrochloride

Refernces

• 1、 Park, Do Young,Kim, Kyung-Hee,Cheon, Cheol-Hong. "Enantioselective Synthesis of β-Aminotetralins via Chiral Phosphoric Acid-catalyzed Reductive Amination of β-Tetralones". supporting information. p. 462 - 467. Retrieved 2017/12/07.
• 2、 -. "Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives". . . Retrieved 2013/05/08.