2,24-Dihydroxyursolic acid

Base Information

• Chemical Name: 2,24-Dihydroxyursolic acid
• CAS No.: 143839-02-5
• Molecular Formula: C₃₀H₄₈O₅
• Molecular Weight: 488.708
• Mol file: 143839-02-5.mol

Synonyms:2,24-Dihydroxyursolicacid; 2a,3b,24-Trihydroxyurs-12-en-28-oic acid

Chemical Property of 2,24-Dihydroxyursolic acid

Chemical Property:

• Melting Point: 242 - 244 °C
• PSA: 97.99000
• LogP: 5.03270

Purity/Quality:

99% ^*data from raw suppliers

2,24-Dihydroxyursolicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,24-Dihydroxyursolic acid

There total 10 articles about 2,24-Dihydroxyursolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.08%

asiaticoside (16830-15-2) → asiatic acid (464-92-6,89786-83-4,103974-74-9,106327-64-4,114580-55-1,116348-15-3,143839-02-5)

Guidance literature:

With water; sodium dodecyl-sulfate; sodium hydroxide; at 20 ℃; for 0.25h; under 760.051 Torr;

Reference yield: 92.0%

asiaticoside → asiatic acid (464-92-6,89786-83-4,103974-74-9,106327-64-4,114580-55-1,116348-15-3,143839-02-5)

Guidance literature:

With water; sodium hydroxide; In methanol; Reflux;

DOI:10.1248/cpb.c13-00328

Reference yield: 47.0%

Asiaticoside → asiatic acid (464-92-6,89786-83-4,103974-74-9,106327-64-4,114580-55-1,116348-15-3,143839-02-5) + 2α,3β,23α-trihydroxyurs-12-en-28-oic acid 28-O-β-D-glucopyranoside

Guidance literature:

With α-L-rhamnosidase from Fusarium oxysporum CCF906; In phosphate buffer; at 35 ℃; for 48h; pH=6.0;

DOI:10.1002/adsc.200505047

upstream raw materials:

asiaticoside

Downstream raw materials:

methyl 2α-hydroxy-3β,23-isopropylidenedioxyurs-12-ene-28-oate

methyl 2α-O-(N-fluorenonemethyoxycarbonyl)-phenyglycylurs-3β,23-isopropylidenedioxyurs-12-ene-28-oate

methyl 2-O-phenyglycylurs-3,23-isopropylidenedioxyurs-12-ene-28-oate

Refernces

• 1、 Huang, Ri-Zhen,Wang, Cai-Yi,Li, Jian-Fei,Yao, Gui-Yang,Pan, Ying-Ming,Ye, Man-Yi,Wang, Heng-Shan,Zhang, Ye. "Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing α-aminophosphonates". . p. 62890 - 62906. Retrieved 2016/07/16.
• 2、 Li, Yong,Yang, Fang,Yuan, Mingxing,Jiang, Lijuan,Yuan, Li,Zhang, Xiaowei,Li, Ying,Dong, Lin,Bao, Xu,Yin, Shufan. "Synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: Structure/activity studies". . p. 44 - 49. Retrieved 2015/02/19.