Indazole-4-boronic acid, hydrochloride

Base Information

• Chemical Name: Indazole-4-boronic acid, hydrochloride
• CAS No.: 1023595-17-6
• Molecular Formula: C7H7BN2O2
• Molecular Weight: 161.956
• Hs Code.: 29339900
• Mol file: 1023595-17-6.mol

Synonyms:Indazole-4-boronic acid, hydrochloride;1H-indazole-4-boronic acid;Boronic acid, B-1H-indazol-4-yl-;1H-indazol-4-yl-4-boronic acid;Indazole-4-boronic acid;1H-indazole-4-boronic aci...;4-Borono-1H-indazole;1H-indazol-4-yl-4-ylboronic acid

Chemical Property of Indazole-4-boronic acid, hydrochloride

Chemical Property:

• Melting Point: 173-177°C
• Boiling Point: 457.012 °C at 760 mmHg
• PKA: 7.92±0.30(Predicted)
• Flash Point: 230.193 °C
• PSA: 69.14000
• Density: 1.423 g/cm³
• LogP: -0.75730
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Indazole-4-boronic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reactant for:Preparation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitorsPreparation of bisphosphonate inhibitors of human farnesyl pyrophosphate synthase

Technology Process of Indazole-4-boronic acid, hydrochloride

There total 1 articles about Indazole-4-boronic acid, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

boric acid tributyl ester (688-74-4) + 4-bromo-1-(triisopropylsilyl)-1H-indazole → (1H-indazol-4-yl)boronic acid (1023595-17-6)

Guidance literature:

With n-butyllithium; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

Reference yield: 91.8%

(1H-indazol-4-yl)boronic acid (1023595-17-6) + C20H27BrN4O4Si → C27H32N6O4Si

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; Microwave irradiation;

Reference yield: 52.6%

(1H-indazol-4-yl)boronic acid (1023595-17-6) + 2-amino-6-bromo-3-phenylquinazolin-4(3H)-one (1383992-15-1) → 2-amino-6-(1H-indazol-4-yl)-3-phenyl-4(3H)-quinazolinone (1383988-57-5)

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 3h;

upstream raw materials:

boric acid tributyl ester

Downstream raw materials:

2-amino-6-(1H-indazol-4-yl)-3-phenyl-4(3H)-quinazolinone

Refernces