(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Base Information

• Chemical Name: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
• CAS No.: 1417576-01-2
• Molecular Formula: C₃₂H₂₈N₄O₈
• Molecular Weight: 596.596
• Mol file: 1417576-01-2.mol

Synonyms:

Chemical Property of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

There total 7 articles about (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

Azilsartan medoxomil (863031-21-4) + ethyl iodide (75-03-6) → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate (1417576-01-2)

Guidance literature:

With potassium carbonate; In acetone; for 24h;

DOI:10.1021/op3002867

Reference yield:

methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate (139481-44-0) → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate (1417576-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 18 h / 90 °C

2: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C

3: sodium hydroxide; water / 3 h / 50 °C

4: potassium carbonate; p-toluenesulfonyl chloride; dmap / N,N-dimethyl acetamide / 3 h / 30 °C

5: potassium carbonate / acetone / 24 h

With dmap; hydroxylamine hydrochloride; water; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; In N,N-dimethyl acetamide; water; dimethyl sulfoxide; acetone;

DOI:10.1021/op3002867

Reference yield:

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate (147403-65-4) → (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate (1417576-01-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 4 h / 20 °C

2: sodium hydroxide; water / 3 h / 50 °C

3: potassium carbonate; p-toluenesulfonyl chloride; dmap / N,N-dimethyl acetamide / 3 h / 30 °C

4: potassium carbonate / acetone / 24 h

With dmap; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; p-toluenesulfonyl chloride; sodium hydroxide; In N,N-dimethyl acetamide; dimethyl sulfoxide; acetone;

DOI:10.1021/op3002867

upstream raw materials:

ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Azilsartan medoxomil

ethyl iodide

Refernces