1-Methyl-2-phenylindolizine

Base Information

• Chemical Name: 1-Methyl-2-phenylindolizine
• CAS No.: 1019-12-1
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• DSSTox Substance ID: DTXSID10474096
• Nikkaji Number: J1.024.980E
• Wikidata: Q82303881
• Mol file: 1019-12-1.mol

Synonyms:1-methyl-2-phenylindolizine;1019-12-1;Indolizine, 1-methyl-2-phenyl-;SCHEMBL1435590;DTXSID10474096

Chemical Property of 1-Methyl-2-phenylindolizine

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 207.104799419
• Heavy Atom Count: 16
• Complexity: 232

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC=CN2C=C1C3=CC=CC=C3

Technology Process of 1-Methyl-2-phenylindolizine

There total 6 articles about 1-Methyl-2-phenylindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Ethylpyridine (100-71-0) + α-bromoacetophenone (70-11-1) → 1-methyl-2-phenylindolizine (1019-12-1)

Guidance literature:

2-Ethylpyridine; α-bromoacetophenone; In acetone; for 21h; Reflux;

With sodium hydrogencarbonate; In water; for 1.5h; Reflux;

Reference yield: 66.0%

2-Ethylpyridine (100-71-0) + Cinnamic acid (621-82-9) → 1-methyl-2-phenylindolizine (1019-12-1)

Guidance literature:

With 1,10-Phenanthroline; lithium acetate; copper diacetate; nickel; In N,N-dimethyl-formamide; at 140 ℃; for 36h; Inert atmosphere;

DOI:10.1021/ol300067h

Reference yield: 10.0%

1-methyl-3-nitroso-2-phenylindolizine (22900-45-4) → 1-methyl-2-phenylindolizine (1019-12-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 2h; Inert atmosphere; Darkness;

upstream raw materials:

2-Ethylpyridine

Cinnamic acid

1-methyl-3-nitroso-2-phenylindolizine

α-bromoacetophenone

Downstream raw materials:

4-chlorobenzenesulfinic acid

(4-Methoxy-phenyl)-(1-methyl-2-phenyl-indolizin-3-yl)-diazene

(1-Methyl-2-phenyl-indolizin-3-yl)-(4-nitro-phenyl)-diazene

1,1'-Dimethyl-2,2'-diphenyl-[3,3']biindolizinyl

Refernces

• 1、 Kalinin, Alexey A.,Smirnov, Maxim A.,Islamova, Liliya N.,Fazleeva, Guzel M.,Vakhonina, Tatyana A.,Levitskaya, Alina I.,Fominykh, Olga D.,Ivanova, Nataliya V.,Khamatgalimov, Ayrat R.,Nizameev, Irek R.,Balakina, Marina Yu.. "Synthesis and characterization of new second-order NLO chromophores containing the isomeric indolizine moiety for electro-optical materials". . p. 444 - 454. Retrieved 2017.
• 2、 -. "INDOLIZINE-BASED DYES FOR DYE-SENSITIZED SOLAR CELL". Page/Page column 33; 37. . Retrieved 2016/04/01.