N-Carboxybenzyl D-Valacyclovir

Base Information

• Chemical Name: N-Carboxybenzyl D-Valacyclovir
• CAS No.: 124832-32-2
• Molecular Formula: C₂₁H₂₆N₆O₆
• Molecular Weight: 458.474
• Mol file: 124832-32-2.mol

Synonyms:

Chemical Property of N-Carboxybenzyl D-Valacyclovir

Chemical Property:

• PKA: 9.34±0.20(Predicted)
• Density: 1.42±0.1 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

N-CarboxybenzylD-Valacyclovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Carboxybenzyl D-Valacyclovir, is a derivative of D-Valacyclovir (V084995), which is a drug used to treat infections caused by certain types of viruses. It is also the D-Valine ester prodrug of Acyclovir (A192400).

Technology Process of N-Carboxybenzyl D-Valacyclovir

There total 1 articles about N-Carboxybenzyl D-Valacyclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + acyclovir (59277-89-3) → CBZ-L-valineacyclovir (124832-32-2)

Guidance literature:

(S)-N-(benzyloxycarbonyl)valine; acyclovir; With dmap; In N,N-dimethyl-formamide; at 5 ℃;

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 10 ℃; for 30h;

Reference yield: 86.0%

CBZ-L-valineacyclovir (124832-32-2) → valacyclovir hydrochloride (124832-27-5,136489-37-7)

Guidance literature:

CBZ-L-valineacyclovir; With formic acid; palladium on activated charcoal; In methanol; water; at 20 - 40 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 20 - 40 ℃; for 10h;

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

acyclovir

Downstream raw materials:

valacyclovir hydrochloride

Refernces