3-(5-FLUORO-2-METHYLPHENYL)PROPIONIC ACID

Base Information

• Chemical Name: 3-(5-FLUORO-2-METHYLPHENYL)PROPIONIC ACID
• CAS No.: 137466-13-8
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Hs Code.: 2916399090
• Mol file: 137466-13-8.mol

Synonyms:

Chemical Property of 3-(5-FLUORO-2-METHYLPHENYL)PROPIONIC ACID

Chemical Property:

• Melting Point: 44-47°

Purity/Quality:

99% ^*data from raw suppliers

3-(5-Fluoro-2-methylphenyl)propionic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(5-FLUORO-2-METHYLPHENYL)PROPIONIC ACID

There total 3 articles about 3-(5-FLUORO-2-METHYLPHENYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 3-(5'-Fluoro-2'-methylphenyl)propanoic acid (137466-13-8)

Guidance literature:

With platinum(IV) oxide; hydrogen; In ethanol; for 3h; under 1551.49 Torr;

Reference yield:

Ethyl 3-(5'-fluoro-2'-methylphenyl)propanoate (137466-12-7) → 3-(5'-Fluoro-2'-methylphenyl)propanoic acid (137466-13-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jo00027a063

Reference yield:

2-bromo-4-fluorotoluene (1422-53-3) → 3-(5'-Fluoro-2'-methylphenyl)propanoic acid (137466-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) CuCl / 1.) diethyl ether, reflux, 2h, 2.) -17 deg C

2: 2 M aq. NaOH

With sodium hydroxide; magnesium; copper(l) chloride;

DOI:10.1021/jo00027a063

upstream raw materials:

Ethyl 3-(5'-fluoro-2'-methylphenyl)propanoate

2-bromo-4-fluorotoluene

Downstream raw materials:

7-Fluoro-4-methyl-1-indanone

Refernces

• 1、 -. "3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE". Paragraph 1435-1438. . Retrieved 2015/04/15.