syn-2-pyridinealdoxime

Base Information

• Chemical Name: syn-2-pyridinealdoxime
• CAS No.: 1193-96-0
• Molecular Formula: C6H6N2O
• Molecular Weight: 122.126
• Hs Code.: 2933399090
• Mol file: 1193-96-0.mol

Synonyms:syn-2-pyridinealdoxime;Picolinaldehyde oxime;

Chemical Property of syn-2-pyridinealdoxime

Chemical Property:

• Vapor Pressure: 0.032mmHg at 25°C
• Melting Point: 110-112oC(lit.)
• Boiling Point: 233.139oC at 760 mmHg
• Flash Point: 94.799oC
• PSA: 45.48000
• Density: 1.141g/cm3
• LogP: 0.88970
• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

syn-2-Pyridinealdoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: syn-2-Pyridinealdoxime is a 2-substituted pyridine derivative with inhibitory activity against prolyl-4-hydroxylase. syn-2-Pyridinealdoxime is used in the preparation of DNA-binding silver nitrate com plexes. syn-2-Pyridinealdoximeis the N-demethylated analogue of AChE inhibitor Pralidoxime (P701120). syn-2-Pyridinealdoxime is a 2-substituted pyridine derivative with inhibitory activity against prolyl-4-hydroxylase. syn-2-Pyridinealdoxime is used in the preparation of DNA-binding silver nitrate complexes. syn-2-Pyridinealdoximeis the N-demethylated analogue of AChE inhibitor Pralidoxime (P701120).

Technology Process of syn-2-pyridinealdoxime

There total 5 articles about syn-2-pyridinealdoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridine-2-carbaldehyde (1121-60-4) → (E)-pyridin-2-aldoxime (1193-96-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.poly.2013.05.024

Reference yield: 80.0%

2-(Aminomethyl)pyridine (3731-51-9) → (E)-pyridin-2-aldoxime (1193-96-0)

Guidance literature:

With Acetaldehyde oxime; 3-methyl-4-oxa-5-azahomoadamantane; oxygen; In water; at 100 ℃; for 10h; Green chemistry;

DOI:10.1002/adsc.201400601

Reference yield:

O-acetyl-2-pyridinecarboxaldoxime (74231-53-1,19433-10-4) → (E)-pyridin-2-aldoxime (1193-96-0) + acetic acid (64-19-7,77671-22-8)

Guidance literature:

With acetate buffer; copper dichloride; In water; acetonitrile; at 25 ℃; Rate constant; Mechanism; Thermodynamic data; deuterium oxide isotope effect, pH 2.00-4.50, E_a, ΔH(excit.), ΔF(excit.), ΔS(excit.);

DOI:10.1021/ja00370a034

upstream raw materials:

2-hydroxyiminomethyl-pyridine

O-acetyl-2-pyridinecarboxaldoxime

pyridine-2-carbaldehyde

2-(Aminomethyl)pyridine

Downstream raw materials:

Contrathion

2,2'-bis-(hydroxyimino-methyl)-1,1'-hexanediyl-bis-pyridinium; dibromide

1-dodecyl-2-(hydroxyimino-methyl)-pyridinium; iodide

O-acetyl-2-pyridinecarboxaldoxime

Refernces

• 1、 Zhang, Xiao-Peng,Liu, Jian,Zhang, Jing-Xuan,Huang, Jia-Hao,Wan, Cheng-Zhang,Li, Cheng-Hui,You, Xiao-Zeng. "Synthesis and ferroelectric properties of platinum(II) complexes with chiral isoxazoline ligand". . p. 85 - 92. Retrieved 2013.
• 2、 Jiang, Xiaoying,Xu, Xiaohe,Lin, Yuyan,Yan, Yiyan,Li, Pingping,Bai, Renren,Xie, Yuanyuan. "A mild system for synthesis of aldoximes and ketoximes in the presence of N-hydroxyphthalimide in aqueous system". supporting information. p. 5879 - 5885. Retrieved 2018/09/06.
• 3、 Yu, Jiatao,Cao, Xiaohua,Lu, Ming. "A novel and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to oximes". supporting information. p. 5751 - 5755. Retrieved 2015/02/02.