Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-

Base Information

• Chemical Name: Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-
• CAS No.: 133699-09-9
• Molecular Formula: C25H28O4
• Molecular Weight: 392.495
• DSSTox Substance ID: DTXSID10473908
• Nikkaji Number: J1.237.146B
• Wikidata: Q82303587
• Mol file: 133699-09-9.mol

Synonyms:Tr-PEG4;133699-09-9;Tr-PEG3-OH;2-(2-(2-(Trityloxy)ethoxy)ethoxy)ethanol;Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-;2-[2-(2-trityloxyethoxy)ethoxy]ethanol;2-(2-(2-(trityloxy)ethoxy)ethoxy)ethan-1-ol;SCHEMBL4454711;DTXSID10473908;CKYIMQGYUMGSEO-UHFFFAOYSA-N;MFCD22574815;AKOS030596506;AS-68509;BP-20703;HY-120258;CS-0077387;2-[2-(2-triphenylmethoxyethoxy)ethoxy]ethanol;2-[2-(2-triphenylmethoxyethoxyl)ethoxy]ethanol;W16656;2-{2-[2-(triphenylmethoxy)ethoxy]ethoxy}ethan-1-ol

Chemical Property of Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-

Chemical Property:

• Boiling Point: 521.8±45.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• PSA: 47.92000
• Density: 1.126±0.06 g/cm3(Predicted)
• LogP: 4.02060
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 12
• Exact Mass: 392.19875937
• Heavy Atom Count: 29
• Complexity: 364

Purity/Quality:

98%min ^*data from raw suppliers

Tr-Peg4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCCOCCOCCO
• Description: Tr-PEG4 is a PEG linker containing a trityl, alcohol protecting group and a terminal hydroxyl group. Trityl can be removed under acidic conditions. The hydroxyl group can undergo various reactions in order to further derivatize the compound. The hydrophilic PEG linkers increase the solubility of compounds in aqueous media.

Technology Process of Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-

There total 3 articles about Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trityl chloride (76-83-5) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol (133699-09-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200701188

Reference yield:

triphenylmethyl alcohol (76-84-6) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol (133699-09-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1002/hlca.19920750808

Reference yield:

→ 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol (133699-09-9)

Guidance literature:

With pyridine;

upstream raw materials:

trityl chloride

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

triphenylmethyl alcohol

Refernces

• 1、 Luo, Shyh-Chyang,Kantchev, Eric Assen B.,Zhu, Bo,Siang, Yuen Wee,Yu, Hsiao-Hua. "Tunable, dynamic and electrically stimulated lectin-carbohydrate recognition on a glycan-grafted conjugated polymer". . p. 6942 - 6944. Retrieved 2012.
• 2、 Singh, Wangkhem P.,Singh, Rajkumar S.. "A new class of organogelators based on triphenylmethyl derivatives of primary alcohols: Hydrophobic interactions alone can mediate gelation". supporting information. p. 138 - 149. Retrieved 2017/02/15.
• 3、 -. "INHIBITORS OF HEPATITIS C VIRUS POLYMERASE". Paragraph 647; 648. . Retrieved 2016/10/11.