C₈₀H₁₀₅N₁₉O₂₁S₂

Base Information

• Chemical Name: C₈₀H₁₀₅N₁₉O₂₁S₂
• CAS No.: 1207982-86-2
• Molecular Formula: C₈₀H₁₀₅N₁₉O₂₁S₂
• Molecular Weight: 1732.96
• Mol file: 1207982-86-2.mol

Synonyms:

Chemical Property of C₈₀H₁₀₅N₁₉O₂₁S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈₀H₁₀₅N₁₉O₂₁S₂

There total 2 articles about C₈₀H₁₀₅N₁₉O₂₁S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dibromomaleimide (1122-10-7) + somatostatin (38916-34-6,66610-27-3,61950-59-2) → C80H105N19O21S2 (1207982-86-2)

Guidance literature:

somatostatin; With tris-(2-carboxyethyl)-phosphine hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 1h; pH=6.2; aq. phosphate buffer;

2,3-dibromomaleimide; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 1h; aq. phosphate buffer;

DOI:10.1021/ja908610s

Reference yield:

2,3-dibromomaleimide (1122-10-7) + Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (40958-31-4) → C80H105N19O21S2 (1207982-86-2)

Guidance literature:

In aq. phosphate buffer; N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.0166667h; pH=6.4; Inert atmosphere;

DOI:10.1039/c4cc02107j

Reference yield:

C80H105N19O21S2 (1207982-86-2) → Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (40958-31-4)

Guidance literature:

With 2-hydroxyethanethiol; at 4 ℃; for 1h;

DOI:10.1021/ja908610s

upstream raw materials:

2,3-dibromomaleimide

somatostatin

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Downstream raw materials:

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Refernces

• 1、 Marculescu, Cristina,Kossen, Hanno,Morgan, Rachel E.,Mayer, Patrick,Fletcher, Sally A.,Tolner, Berend,Chester, Kerry A.,Jones, Lyn H.,Baker, James R.. "Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds". supporting information. p. 7139 - 7142. Retrieved 2014/07/07.