21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione 21-Acetate

Base Information

• Chemical Name: 21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione 21-Acetate
• CAS No.: 82423-35-6
• Molecular Formula: C₂₃H₂₆O₅
• Molecular Weight: 382.456
• Mol file: 82423-35-6.mol

Synonyms:

Chemical Property of 21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione 21-Acetate

Chemical Property:

• Melting Point: 166-168°C
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, DMSO

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione 21-Acetate

There total 3 articles about 21-Hydroxy-pregna-1,4,16-triene-3,11,20-trione 21-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

17α,21-diacetoxypregna-1,4-diene-3,11,20-trione (6677-19-6) → 21-acetoxypregna-1,4,16-triene-3,11,20-trione (82423-35-6)

Guidance literature:

With sodium acetate; In tetrahydrofuran; at 95 - 100 ℃; for 4.5h; Inert atmosphere;

Reference yield: 83.5%

prednisone acetate (125-10-0) → 21-acetoxypregna-1,4,16-triene-3,11,20-trione (82423-35-6)

Guidance literature:

prednisone acetate; With pyridine; N-chloro-succinimide; sulfur dioxide; at 15 ℃; for 1h; Large scale;

With hydrogenchloride; In water; at 0 ℃; for 5h; Temperature; Large scale;

Reference yield:

Prednison (53-03-2) → 21-acetoxypregna-1,4,16-triene-3,11,20-trione (82423-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2.5 h / 85 - 90 °C

2: sodium acetate / tetrahydrofuran / 4.5 h / 95 - 100 °C / Inert atmosphere

With pyridine; sodium acetate; In tetrahydrofuran;

upstream raw materials:

17α,21-diacetoxypregna-1,4-diene-3,11,20-trione

Prednison

prednisone acetate

Refernces

• 1、 -. "A synthesis method of budesonide (by machine translation)". Paragraph 0024; 0025; 0026; 0034; 0042; 0050. . Retrieved 2018/07/30.
• 2、 Barton, Derek H.R.,Lister-James, John,Hesse, Robert H.,Pechet, Maurice M.,Rozen, Shlomo. "Electrophilic Fluorination of Some Steroidal α,β-Unsaturated Ketones". . p. 1105 - 1110. Retrieved 2007/10/02.