Cph-Cha-Dab-Glu-Phe-Cha

Base Information

• Chemical Name: Cph-Cha-Dab-Glu-Phe-Cha
• CAS No.: 1186310-44-0
• Molecular Formula: C₄₅H₆₄ClN₇O₉
• Molecular Weight: 882.498
• Mol file: 1186310-44-0.mol

Synonyms:

Chemical Property of Cph-Cha-Dab-Glu-Phe-Cha

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cph-Cha-Dab-Glu-Phe-Cha

There total 1 articles about Cph-Cha-Dab-Glu-Phe-Cha which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Fmoc L-Phe (35661-40-6) + Fmoc-Glu(OtBu)-OH (71989-18-9) + (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid (125238-99-5,114360-56-4) + (S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid (135673-97-1) + N-[(9-fluorenyl)methoxycarbonyl]-4-chloro-L-phenylalanine → Cph-Cha-Dab-Glu-Phe-Cha (1186310-44-0)

Guidance literature:

(S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid; With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.416667h; Automated synthesizer; solid phase reaction;

With acetic anhydride; In N,N-dimethyl-formamide; for 0.0833333h; Automated synthesizer; solid phase reaction;

N-Fmoc L-Phe; Fmoc-Glu(OtBu)-OH; (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid; (S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid; N-[(9-fluorenyl)methoxycarbonyl]-4-chloro-L-phenylalanine; Further stages;

DOI:10.1016/j.bmc.2009.05.045

upstream raw materials:

N-Fmoc L-Phe

Fmoc-Glu(OtBu)-OH

(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

(S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid

Refernces