Nal-Nle-Dab-Glu-Hph-Nva

Base Information

• Chemical Name: Nal-Nle-Dab-Glu-Hph-Nva
• CAS No.: 1349220-85-4
• Molecular Formula: C₄₃H₅₉N₇O₉
• Molecular Weight: 817.983
• Mol file: 1349220-85-4.mol

Synonyms:

Chemical Property of Nal-Nle-Dab-Glu-Hph-Nva

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nal-Nle-Dab-Glu-Hph-Nva

There total 1 articles about Nal-Nle-Dab-Glu-Hph-Nva which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Glu(OtBu)-OH (71989-18-9) + N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine (132684-59-4,186320-01-4) + Fmoc-(S)-2-aminohexanoic acid (77284-32-3,144701-20-2) + Fmoc-norvaline-OH (135112-28-6) + (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid (125238-99-5,114360-56-4) + N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine (138774-94-4,186320-03-6) → Nal-Nle-Dab-Glu-Hph-Nva (1349220-85-4)

Guidance literature:

Fmoc-norvaline-OH; With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.416667h; Automated synthesizer; solid phase reaction;

With acetic anhydride; In N,N-dimethyl-formamide; for 0.0833333h; Automated synthesizer; solid phase reaction;

Fmoc-Glu(OtBu)-OH; N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine; Fmoc-(S)-2-aminohexanoic acid; (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid; N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine; Further stages;

DOI:10.1016/j.bmc.2009.05.045

upstream raw materials:

Fmoc-Glu(OtBu)-OH

N-(fluorenyl-9-methoxycarbonyl)-L-homophenylalanine

Fmoc-(S)-2-aminohexanoic acid

Fmoc-norvaline-OH

Refernces