4-Morpholineacetamide, N-[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-meth ylethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl] -

Base Information

• Chemical Name: 4-Morpholineacetamide, N-[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-meth ylethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl] -
• CAS No.: 147284-80-8
• Molecular Formula: C31H45F3N4O5Si
• Molecular Weight: 638.803
• Mol file: 147284-80-8.mol

Synonyms:

Chemical Property of 4-Morpholineacetamide, N-[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-meth ylethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl] -

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Morpholineacetamide, N-[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-meth ylethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl] -

There total 2 articles about 4-Morpholineacetamide, N-[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-meth ylethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl] - which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-acetamide (147284-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: WSCDI, HOBT, DMAP / CH₂Cl₂

With dmap; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00046a016

Reference yield:

morpholin-4-ylacetic acid (3235-69-6) + 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147283-34-9) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-acetamide (147284-80-8)

Guidance literature:

With dmap; benzotriazol-1-ol; In dichloromethane;

DOI:10.1021/jm00046a016

Reference yield:

N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-acetamide (147284-80-8) → 2-[3-(2-Morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide (147284-84-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4.5h;

DOI:10.1021/jm00046a016

upstream raw materials:

morpholin-4-ylacetic acid

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Downstream raw materials:

2-[3-(2-Morpholin-4-yl-acetylamino)-2-oxo-6-phenyl-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide

Refernces