2-Bromo-6-fluoronaphthalene

Base Information

• Chemical Name: 2-Bromo-6-fluoronaphthalene
• CAS No.: 324-41-4
• Molecular Formula: C10H6 Br F
• Molecular Weight: 225.06
• Hs Code.: 2903999090
• Mol file: 324-41-4.mol

Synonyms:2-Bromo-6-fluoronaphthalene;6-Bromo-2-fluoronaphthalene; NSC 403022

Chemical Property of 2-Bromo-6-fluoronaphthalene

Chemical Property:

• Vapor Pressure: 0.00451mmHg at 25°C
• Melting Point: 64.0 to 68.0 °C
• Boiling Point: 286.6 ºC at 760 mmHg
• Flash Point: 130.8 ºC
• PSA: 0.00000
• Density: 1.563 g/cm³
• LogP: 3.74140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-fluoronaphthalene

There total 6 articles about 2-Bromo-6-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

6-fluoro-2-naphthoyl chloride (87700-58-1) → 2-bromo-6-fluoronaphthalene (324-41-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; 2-mercaptopyridine-1-oxide sodium salt; at 100 ℃; for 0.75h;

Reference yield:

6-Bromonaphthalen-2-amine (7499-66-3) → 2-bromo-6-fluoronaphthalene (324-41-4)

Guidance literature:

6-Bromonaphthalen-2-amine; With hydrogenchloride; hexafluorophosphoric acid; sodium nitrite; at 0 ℃;

DOI:10.1016/S0968-0896(00)00117-6

Reference yield:

6-Brom-naphthalin-diazonium-(2) → 2-bromo-6-fluoronaphthalene (324-41-4)

Guidance literature:

In paraffin; at 130 - 140 ℃;

DOI:10.1021/ja00978a038

upstream raw materials:

6-Bromonaphthalen-2-amine

6-bromo-naphthalen-2-ol

6-fluoro-2-naphthoic acid

6-fluoro-2-naphthoyl chloride

Downstream raw materials:

2-(6-Fluor-naphthoyl-⁽²⁾)-benzoesaeure

(6-fluoronaphthalen-2-yl)methanol

6-fluoro-2-naphthaldehyde

Refernces

• 1、 -. "NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT". Page/Page column 28; 48-49. . Retrieved 2010/11/30.