5-CHLORO-DL-TRYPTOPHAN

Base Information

• Chemical Name: 5-CHLORO-DL-TRYPTOPHAN
• CAS No.: 154-07-4
• Molecular Formula: C11H11ClN2O2
• Molecular Weight: 238.67
• Hs Code.: 2933990090
• Mol file: 154-07-4.mol

Synonyms:DL-Tryptophan, 5-chloro-;5-Chloro-DL-tryptophan;Tryptophan, 5-chloro-, DL- (8CI);

Chemical Property of 5-CHLORO-DL-TRYPTOPHAN

Chemical Property:

• Vapor Pressure: 6.66E-10mmHg at 25°C
• Refractive Index: 1.701
• Boiling Point: 476.906 °C at 760 mmHg
• Flash Point: 242.224 °C
• PSA: 79.11000
• Density: 1.475 g/cm³
• LogP: 2.47600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Aqueous Acid (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

5-Chloro-DL-tryptophan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-DL-TRYPTOPHAN

There total 19 articles about 5-CHLORO-DL-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-chloro-L-tryptophan methyl ester (93299-36-6,93299-37-7) → 5-chloro-L-tryptophan (154-07-4,52448-15-4,55325-48-9,69483-00-7)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield: 50.0%

5-chloro-D-tryptophan methyl ester (93299-36-6,93299-37-7) → 5-chloro-D-tryptophan (154-07-4,52448-15-4,55325-48-9,69483-00-7)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield:

C17H19ClN2O5 → 2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid (154-07-4)

Guidance literature:

C₁₇H₁₉ClN₂O₅; With sodium hydroxide; In water; at 100 ℃; for 7h;

With acetic acid; In water; at 130 ℃;

upstream raw materials:

acetylamino-(5-chloro-indol-3-ylmethyl)-malonic acid diethyl ester

(2S^*,3aR^*,8aR^*)-8-acetyl-5-chloro-1,2-bis(methoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole

DL-(2β,3aα,8aα)-8-acetyl-1,2-dimethoxycarbonyl-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole

3-(dimethylaminomethyl)-5-chloro-1H-indole

Downstream raw materials:

Boc-5-Cl-Trp-OH

D-5-chlorotryptophan

5-(5-chloro-indol-3-ylmethyl)-3-[3-(4-phenyl-piperidin-1-yl)-propyl]-imidazolidine-2,4-dione

tert-butyl 2-(5-chloro-1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Refernces

• 1、 Irie, Kunihiko,Ishida, Akihiko,Nakamura, Tohru,Oh-ishi, Tokuro. "Syntheses of Substituted L- and D-Tryptophans". . p. 2126 - 2139. Retrieved 2007/10/02.