4,6-DiMethyl-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 4,6-DiMethyl-2-hydroxybenzaldehyde
• CAS No.: 1666-02-0
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 2912499000
• Mol file: 1666-02-0.mol

Synonyms:4,6-Dimethyl-heptan-2-on;2-Heptanone,4,6-dimethyl;4,6-dimethyl salicylaldehyde;4,6-dimethyl-2-hydroxybenzaldehyde;2,4-dimethyl-6-heptanone;3-Cyan-4,6-dimethyl-5-nitro-pyrid-2-on;4,6-dimethyl-2-heptanone;iso-diisobutyl ketone;4,6-Dimethyl-2-Heptanon;2-hydroxy-4,6-dimethyl-5-nitro-nicotinonitrile;2-hydroxy-4,6-dimethyl-benzaldehyde;5-Cyan-2,4-dimethyl-3-nitro-pyrid-6-on;4,6-Dimethyl-2-hydroxy-5-nitro-nicotinonitril;2-Hydroxy-4,6-dimethyl-benzaldehyd;4,6-dimethyl-heptan-2-one;

Chemical Property of 4,6-DiMethyl-2-hydroxybenzaldehyde

Chemical Property:

• Melting Point: 48-49 °C(Solv: methanol (67-56-1))
• Boiling Point: 140 °C(Press: 29 Torr)
• PKA: 8.39±0.15(Predicted)
• PSA: 37.30000
• Density: 1.136±0.06 g/cm3(Predicted)
• LogP: 1.82150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

2-Hydroxy-4,6-dimethyl-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DiMethyl-2-hydroxybenzaldehyde

There total 17 articles about 4,6-DiMethyl-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 2-hydroxy-4,6-dimethylbenzaldehyde (1666-02-0)

Guidance literature:

3,5-Dimethylphenol; With triethylamine; magnesium chloride; In acetonitrile; for 0.25h;

formaldehyd; for 3h; Heating;

DOI:10.1016/j.jorganchem.2005.03.043

Reference yield: 84.0%

3,5-Dimethylphenol (108-68-9,50356-23-5) + paraformaldehyde → 2-hydroxy-4,6-dimethylbenzaldehyde (1666-02-0)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; for 4h; Heating / reflux;

Reference yield: 71.9%

3,5-Dimethylphenol (108-68-9,50356-23-5) → 2-hydroxy-4,6-dimethylbenzaldehyde (1666-02-0)

Guidance literature:

3,5-Dimethylphenol; With triethylamine; magnesium chloride; In acetonitrile; at 25 ℃; for 0.5h; Inert atmosphere;

polyoxymethylene; In acetonitrile; at 75 ℃; for 3h; Inert atmosphere;

upstream raw materials:

hexamethylenetetramine

3,5-Dimethylphenol

chloroform

3,5-dimethyl-2,4-hexadienoic acid

Downstream raw materials:

2-hydroxy-4,6-dimethyl-benzaldehyde-(2-hydroxy-4,6-dimethyl-benzylimine)

3,6-dihydroxy-2,4-dimethyl-benzaldehyde

2-hydroxy-4,6-dimethyl-benzyl alcohol

2-hydroxy-4,6-dimethyl-benzaldehyde-oxime

Refernces

• 1、 Hansen, Poul Erik,Kamounah, Fadhil S.,Saeed, Bahjat A.,MacLachlan, Mark J.,Spanget-Larsen, Jens. "Intramolecular hydrogen bonds in normal and sterically compressed o-hydroxy aromatic aldehydes. Isotope effects on chemical shifts and hydrogen bond strength". . . Retrieved 2019.
• 2、 Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu. "Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers". . p. 587 - 593. Retrieved 2019/07/22.