Technology Process of Benzenebutanoyl chloride, 4-[bis(2-chloroethyl)amino]-
There total 6 articles about Benzenebutanoyl chloride, 4-[bis(2-chloroethyl)amino]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloroformic acid ethyl ester; triethylamine;
In
acetone;
at 0 ℃;
for 0.25h;
DOI:10.1021/jm00173a016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Pd/C / ethyl acetate
2: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C
3: POCl3 / benzene / 1 h / Heating
4: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min
5: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C
With
hydrogenchloride; hydrogen; chloroformic acid ethyl ester; acetic acid; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; ethyl acetate; acetone; benzene;
DOI:10.1021/jm00173a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid
2: phosphorus oxychloride / toluene / Heating
3: hydrochloric acid / Heating
4: thionyl chloride / CH2Cl2 / 4 °C
With
hydrogenchloride; thionyl chloride; acetic acid; trichlorophosphate;
In
dichloromethane; toluene;
DOI:10.1016/j.bmc.2003.09.006
