tert-Butyl thiomorpholine-4-carboxylate

Base Information

• Chemical Name: tert-Butyl thiomorpholine-4-carboxylate
• CAS No.: 215791-95-0
• Molecular Formula: C9H17NO4S
• Molecular Weight: 235.304
• Mol file: 215791-95-0.mol

Synonyms:N-tert-butoxycarbonyl-thiomorpholinesulfone;tert-Butyl 1,1-dioxothiomorpholine-4-carboxylate;tert-butyl-1,1-dioxo-4-thiomorpholinecarboxylate;N-tert-butyloxycarbonyl thiomorpholine 1,1-dioxide;N-BOC-THIOMORPHOLINESULFONE;N-BOC-1,1-dioxothiomorpholine;

Chemical Property of tert-Butyl thiomorpholine-4-carboxylate

Chemical Property:

• Boiling Point: 390.7±35.0 °C(Predicted)
• PKA: -1.87±0.20(Predicted)
• PSA: 72.06000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 1.67060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl thiomorpholine-4-carboxylate

There total 5 articles about tert-Butyl thiomorpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiomorpholine 1,1-dioxide (39093-93-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl thiomorpholine-4-carboxylic acid-1,1-dioxide (215791-95-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 88.0%

tert-butyl thiomorpholine-4-carboxylate (220655-09-4) → tert-butyl thiomorpholine-4-carboxylic acid-1,1-dioxide (215791-95-0)

Guidance literature:

With dihydrogen peroxide; In acetic acid; at 0 - 50 ℃; for 4h;

DOI:10.1016/j.ejmech.2018.09.004

Reference yield: 82.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,1-dioxothiomorpholine hydrochloride (59801-62-6) → tert-butyl thiomorpholine-4-carboxylic acid-1,1-dioxide (215791-95-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

thiomorpholine 1,1-dioxide

di-tert-butyl dicarbonate

tert-butyl thiomorpholine-4-carboxylate

1,1-dioxothiomorpholine hydrochloride

Downstream raw materials:

N-(tert-butoxycarbonyl)-3-pyrroline

thiomorpholine 1,1-dioxide

1,1-dioxothiomorpholine hydrochloride

Refernces

• 1、 -. "PYRROLIDINE GLYCOSIDASE INHIBITORS". Page/Page column 184. . Retrieved 2020/03/15.
• 2、 Wu, Yachuang,Ding, Xiudong,Ding, Liang,Zhang, Yongsheng,Cui, Lei,Sun, Lu,Li, Wei,Wang, Di,Zhao, Yanfang. "Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents". . p. 247 - 258. Retrieved 2018/09/18.