1-IODO-2,4,5-TRIMETHOXYBENZENE

Base Information

• Chemical Name: 1-IODO-2,4,5-TRIMETHOXYBENZENE
• CAS No.: 23149-33-9
• Molecular Formula: C9H11IO3
• Molecular Weight: 294.089
• Hs Code.: 2909309090
• Mol file: 23149-33-9.mol

Synonyms:1-iodo-2,4,5-trimethoxy-benzene;5-iodo-1,2,4-trimethoxybenzene;1-Jod-2,4,5-trimethoxy-benzol;

Chemical Property of 1-IODO-2,4,5-TRIMETHOXYBENZENE

Chemical Property:

• Vapor Pressure: 0.000433mmHg at 25°C
• PSA: 27.69000
• LogP: 2.31700

Purity/Quality:

1-IODO-2,4,5-TRIMETHOXYBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-IODO-2,4,5-TRIMETHOXYBENZENE

There total 7 articles about 1-IODO-2,4,5-TRIMETHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,4-trimethoxy-benzene (135-77-3) → 1-iodo-2,4,5-trimethoxybenzene (23149-33-9)

Guidance literature:

With iodine; silver trifluoroacetate; In dichloromethane; at 0 ℃; for 8h;

DOI:10.1039/c0ob00616e

Reference yield: 51.0%

asaronic acid (490-64-2) → 1-iodo-2,4,5-trimethoxybenzene (23149-33-9)

Guidance literature:

With copper(l) iodide; oxygen; palladium diacetate; In dimethyl sulfoxide; at 160 ℃; for 20h; under 760.051 Torr; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.5b02873

Reference yield: 51.0%

1-bromo-2,4,5-trimethoxybenzene (20129-11-7) → 1-iodo-2,4,5-trimethoxybenzene (23149-33-9)

Guidance literature:

With n-butyllithium; iodine; In tetrahydrofuran; hexane; for 2h; Ambient temperature;

upstream raw materials:

1,2,4-trimethoxy-benzene

1-bromo-2,4,5-trimethoxybenzene

methanol

iodine

Downstream raw materials:

2,2',4,4',5,5'-hexamethoxybiphenyl

1-bromo-2,4,5-trimethoxybenzene

methyl 2,4,5-trimethoxycinnamate

1,2,5-trimethoxy-4-(3-methylbut-3-en-1-ynyl)benzene

Refernces

• 1、 Pavlinac, Jasminka,Zupan, Marko,Stavber, Stojan. "'Green' iodination of dimethoxy- and trimethoxy-substituted aromatic compounds using an iodine-hydrogen peroxide combination in water". . p. 2603 - 2607. Retrieved 2006.
• 2、 Fu, Zhengjiang,Jiang, Ligao,Zuo, Qianming,Li, Zhaojie,Liu, Yanzhu,Wei, Zhenhong,Cai, Hu. "Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions". supporting information. p. 5416 - 5421. Retrieved 2018/08/12.
• 3、 -. "Synthetic method of marine natural product Puupehenol". Paragraph 0013. . Retrieved 2017/06/02.