1001258-87-2

Basic information

• Product Name: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol
• Synonyms: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol
• CAS NO: 1001258-87-2
• Molecular Weight: 436.505
• Mol File: 1001258-87-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol(1001258-87-2)
• EPA Substance Registry System: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol(1001258-87-2)

Safety Data

• Hazardous Substances Data: 1001258-87-2(Hazardous Substances Data)

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 676596-82-0 (E)-2-bromo-1,5-dimethoxy-3-(4-methoxystyryl)benzene 
• 906457-43-0 (E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde 
• 322640-05-1 3,5-dimethoxyphenyl magnesium bromide 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 81574-69-8 2-bromo-4,6-dimethoxybenzaldehyde 
• 637-69-4 4-Methoxystyrene 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 

Downstream Products

• 1001259-14-8 (E)-(2,4-dimethoxy-6-(4-methoxystyryl)phenyl)(3,5-dimethoxyphenyl)methanone 
• 1133711-34-8 C₂₆H₂₆O₆ 
• 1377399-63-7 C₅₆H₄₆O₆ 

Relevant articles and documents

Selective Divergent Synthesis of Indanols, Indanones, and Indenes via Acid-Mediated Cyclization of (Z)- and (E)-(2-Stilbenyl)methanols and Its Application for the Synthesis of Paucifloral F Derivatives

Starting from bromo/iodobenzaldehyde derivatives, the corresponding (Z)- and (E)-(2-stilbenyl)methanols could be prepared in 2-5 steps via Pd-catalyzed cross-coupling reactions (Sonogashira and Heck reactions) followed by aryllithium/aryl Grignard addition. For the (E)-stilbenes, subsequent acid-mediated cyclization using p-TsOH immobilized on silica (PTS-Si) at low temperatures furnished the 2,3-trans-1-indanols with complete stereocontrol at the C2-C3. Further oxidization of the alcohol provided the indanones, which are structurally related to the natural product paucifloral F. At higher temperatures, 1,2- and 2,3-disubstituted indenes could be selectively prepared in good to excellent yields. On the other hand, the (Z)-stilbenes, under similar conditions (PTS-Si), did not give the indanols; only the 1,2-disubstituted indenes could be obtained. To gain further insights into the stereochemistry at C2-C3 for the (Z)-stilbenes, hydride or azide was employed as a nucleophile; the corresponding indane products were obtained with the cis stereochemistry at the C2-C3. Thus, the (Z)- or (E)-olefin geometry of the substrate directed the stereoselective indanyl cyclization to furnish the cis or trans at the C2-C3 ring junction, respectively, while reaction conditions controlled the selectivity of the product types.

RESVERATROL-BASED COMPOUNDS

The invention provides a compound having the structure compound having the structure: Formula wherein bond a is present or absent, wherein when bond a is absent, then bond β is: Sign (I) and R1 is: Formula and when bond a is present, then Rsub

Modular synthesis of polyphenolic benzofurans, and application in the total synthesis of malibatol A and shoreaphenol

A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant polyphenols.