1009-06-9

Basic information

• Product Name: Acetamide, N-(2-bromo-5-fluorophenyl)-
• CAS NO: 1009-06-9
• Molecular Formula: C8H7BrFNO
• Molecular Weight: 232.052
• Mol File: 1009-06-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(2-bromo-5-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(2-bromo-5-fluorophenyl)-(1009-06-9)
• EPA Substance Registry System: Acetamide, N-(2-bromo-5-fluorophenyl)-(1009-06-9)

Safety Data

• Hazardous Substances Data: 1009-06-9(Hazardous Substances Data)

Usage

Description

Acetamide, N-(2-bromo-5-fluorophenyl)-, is a chemical compound belonging to the acetamides class, featuring a bromo and fluorine-substituted phenyl group. This unique structure endows it with distinctive chemical properties, making it a valuable intermediate in the synthesis of a variety of biologically active compounds. Its presence in pharmaceutical research and drug development is significant, as it serves as a building block for creating diverse pharmaceuticals and agrochemicals, with potential applications in materials science as well.

Uses

Used in Pharmaceutical Research and Drug Development:
Acetamide, N-(2-bromo-5-fluorophenyl)is utilized as a key building block for the synthesis of biologically active compounds. Its unique chemical properties, including the presence of bromine and fluorine, make it an essential component in the development of new pharmaceuticals with specific therapeutic targets.
Used in Agrochemical Development:
Acetamide, N-(2-bromo-5-fluorophenyl)also finds application in the agrochemical industry, where its diverse reactivity and functional groups contribute to the creation of effective and targeted agrochemical products.
Used in Materials Science:
Due to its potential for diverse reactions and the presence of multiple functional groups, Acetamide, N-(2-bromo-5-fluorophenyl)is employed in materials science for the development of new materials with specialized properties.

Upstream product

• 351-28-0 N-(3-fluorophenyl)acetamide 
• 372-19-0 meta-fluoroaniline 
• 127-19-5 N,N-dimethyl acetamide 
• 1003-99-2 2-bromo-5-fluoroaniline 
• 108-24-7 acetic anhydride 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 506-96-7 Acetyl bromide 

Downstream Products

• 399-75-7 5-fluoro-2-methyl-1,3-benzothiazole 
• 1003961-38-3 C₂₁H₂₈BrFN₂O₃ 
• 1356388-73-2 2-(2-acetamido-4-fluorophenyl)pyridine 1-oxide 
• 347-71-7 N-(2-chloro-5-fluorophenyl)acetamide 

Relevant articles and documents

BENZIMIDAZOLE COMPOUNDS AS HDAC6 INHIBITORS

Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

In a search for potent antileishmanial drug candidates, eighteen rhodacyanine analogues bearing fluorine or perfluoroalkyl substituents at various positions were synthesized. These compounds were tested for their inhibitory activities against Leishmania martiniquensis and L. orientalis. This ‘fluorine-walk’ analysis revealed that the introduction of fluorine atom at C-5, 6, 5′, or 6′ on the benzothiazole units led to significant enhancement of the activity, correlating with the less negative reduction potentials of the fluorinated analogues confirmed by the electrochemical study. On the other hand, [sbnd]CF3 and [sbnd]OCF3 groups were found to have detrimental effects, which agreed with the poor aqueous solubility predicted by the in silico ADMET analysis. In addition, some of the analogues including the difluorinated species showed exceptional potency against the promastigote and axenic amastigote stages (IC50 = 40–85 nM), with the activities surpassing both amphotericin B and miltefosine.

Synthesis method and intermediate for 2-bromo-5-fluoro-4-nitroaniline

The invention discloses a synthesis method and an intermediate for 2-bromo-5-fluoro-4-nitroaniline. The synthesis method for 2-bromo-5-fluoro-4-nitroaniline comprises the step of carrying out a nitration reaction on 2-bromo-5-fluoroaniline and a nitration reagent to generate the 2-bromo-5-fluoro-4-nitroaniline, or comprises the following steps: reacting the 2-bromo-5-fluoroaniline with an amino protection reagent to obtain amino-protected 2-bromo-5-fluoroaniline, then carrying out the nitration reaction on the amino-protected 2-bromo-5-fluoroaniline and the nitration reagent to generate a nitration product that is the intermediate, and finally, removing the amino protection group from the nitration product to obtain the 2-bromo-5-fluoro-4-nitroaniline. The synthesis method has the advantages of high reaction yield, high product purity and easily available raw materials.