10102-18-8 Usage
Description
Sodium selenite, with the chemical formula Na2O3Se, is an inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio. It is a white colored crystalline solid that is soluble in water and more dense than water. Sodium selenite can form pentahydrate and is stable in air, although it can lose water in dry air. It is also insoluble in ethanol and has a theoretical selenium content of 45.7%. As a toxic substance, contact with sodium selenite may irritate skin, eyes, and mucous membranes, and it is toxic by ingestion, inhalation, and skin absorption.
Uses
Used in Glass and Enamel Industry:
Sodium selenite is used as a colorant in the production of red enamels and in the manufacture of clear red glass. It helps in removing the green color from glass during its production process.
Used in Cancer Prevention:
Sodium selenite is used as a reducing agent in carcinogenesis with a potency greater than selenomethionine. It has potential applications in cancer prevention and treatment.
Used as an Alkaloidal Reagent:
Sodium selenite is used as an alkaloidal reagent in various chemical reactions and processes.
Used in Nutrition Enhancement:
Sodium selenite is used as a nutrition enhancer, particularly in the animal feed industry. Selenium is a component of glutathione peroxidase, which maintains the function of the cell membrane through oxidation and increases the production of protein lipid-based endogenous antioxidants. It is involved in energy conversion, metabolism, fat emulsification and absorption, and the absorption of various vitamins. Additionally, selenium plays a role in the synthesis of coenzyme A and coenzyme Q, affects the function of other enzyme systems, and influences the metabolism of amino acids, protein synthesis, carbohydrate metabolism, and biological oxidation. A lack of selenium in livestock and poultry can seriously affect their growth and reproduction.
Preparation
(1) Selenite reacts with sodium hydroxide to produce sodium selenite. Further refinement and addition of dilution agent to obtain the final product.
(2) Selenium reacts with nitric acid to produce selenium oxide, which reacts with sodium hydroxide to produce sodium selenite. Followed drying and grinding to obtain the final product.
Toxicity grading
Highly toxic
Acute toxicity
Oral-rat LD50: 7 mg/kg; oral-mouse LD50: 7.08 mg/kg.
Flammability Hazardous Characteristics
Non-combustible; gives off toxic fume of selenium oxide in a fire.
Storage and Transport
Stored in a well-ventilated area, at low temperature, and dry condition; food should be stored and transported separately.
Extinguishing agent
Sand, water.
Occupational standards
TLV-TWA 0.2 mg (Selenium)/m3; STEL 0.3 mg (Selenium)/m3.
Air & Water Reactions
Soluble in water.
Reactivity Profile
Sodium selenite is incompatible with strong acids.
Hazard
Toxic by ingestion.
Health Hazard
Toxic by ingestion. In humans, a concentration of 5 ppm in food or 0.5 ppm in milk or water has been estimated to be dangerous. Elemental selenium has low acute systemic toxicity, but dust or fumes can cause serious irritation of the respiratory tract.
Fire Hazard
May burn but will not ignite readily. When heated to decomposition, may emit toxic fumes of selenium and sodium oxide. Stable in air.
Flammability and Explosibility
Nonflammable
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, subcutaneous, intracervical, parenteral, and intramuscular routes. Experimental teratogenic and reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of Se and Na2O. See also SELENIUM COMPOUNDS.
Potential Exposure
Sodium selenite is used in glass manufacturing and as an alkaloidal reagent; for removing green color from glass during its manufacture; alkaloidal reagent; reagent in bacteriology; testing germination of seeds; decorating porcelain; as a livestock feed additive.
Shipping
UN2630 Selenates or Selenites, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise sodium selenite from a saturated aqueous solution where its solubility is 68% at 20o to give the pentahydrate salt. This yields the anhydrous salt on heating at 40o. [Fehér in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 431 1963].
Incompatibilities
The aqueous solution is a medium strong base. Reacts with water, strong acids; hot surfaces; causing decomposition and a toxic hazard.
Waste Disposal
Liquid or solid: make a strongly acidic solution using hydrochloric acid. Slowly add sodium sulfite to the cold solution. Stir mixture producing sulfur dioxide. Heat, forming dark-gray selenium and black tellurium. Let stand overnight. Filter and dry. Ship to supplier.
Check Digit Verification of cas no
The CAS Registry Mumber 10102-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,0 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10102-18:
(7*1)+(6*0)+(5*1)+(4*0)+(3*2)+(2*1)+(1*8)=28
28 % 10 = 8
So 10102-18-8 is a valid CAS Registry Number.
InChI:InChI=1/Na.OSe/c;1-2/q+1;+2
10102-18-8Relevant articles and documents
Matrix Isolation and Mass Spectrometric Studies of the Vaporization of Alkali Metal Oxoselenium Salts: Characterization of Molecular M2SeO4, M2SeO3, and MSeO2
Brisdon, Alan K.,Gomme, Robin A.,Ogden, J. Steven
, p. 2927 - 2931 (2007/10/02)
Solid samples of alkali metal selenates (M2SeO4) and selenites (M2SeO3) have been heated in vacuo, and the vaporization products studied by using a combination of mass spectrometric and matrix isolation IR techniques.Although some decomposition was observed, evidence was obtained for the existence of the ternary molecular salts M2SeO4 and M2SeO3 (M = Na, K, Rb, Cs) and also for the novel Se(III) species MSeO2.The molecular symmetries are identified as D2d, Cs, and C2v respectively, on the basis of vibrational selection rules, and the various O-Se-O bond angles in these species are estimated from selenium isotope shifts and relative band intensities.
