1011758-03-4 Usage
Description
Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) is a chemical compound that is identified as an impurity in the synthesis or formulation of Quetiapine, a pharmaceutical drug. It is characterized by its unique molecular structure, which includes a dibenzo[b,f][1,4]thiazepine core with an ethylpiperazinyl substituent and a fumarate counterion. This impurity is significant in the context of drug development and quality control, as it can impact the safety, efficacy, and purity of the final drug product.
Uses
Used in Pharmaceutical Industry:
Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) is used as a reference compound for quality control and analytical testing in the pharmaceutical industry. It helps in the identification, quantification, and control of impurities in Quetiapine drug products, ensuring that they meet the required standards for safety, efficacy, and purity.
Used in Research and Development:
In the field of research and development, Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) serves as a valuable tool for studying the chemical and pharmacological properties of Quetiapine and its related compounds. It can be used to investigate the mechanisms of action, potential side effects, and interactions with other drugs or biological systems.
Used in Regulatory Compliance:
Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) is also utilized in the regulatory compliance process, as it is necessary for pharmaceutical companies to demonstrate that their drug products are free from harmful impurities or contain them within acceptable limits. This impurity can be used as a benchmark for setting regulatory standards and guidelines for the manufacture and distribution of Quetiapine-containing medications.
Check Digit Verification of cas no
The CAS Registry Mumber 1011758-03-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,1,7,5 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1011758-03:
(9*1)+(8*0)+(7*1)+(6*1)+(5*7)+(4*5)+(3*8)+(2*0)+(1*3)=104
104 % 10 = 4
So 1011758-03-4 is a valid CAS Registry Number.
1011758-03-4Relevant articles and documents
Refining method of quetiapine fumarate
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Paragraph 0028-0031, (2021/01/29)
The invention provides a refining method of quetiapine hemifumarate. The refining method comprises the following steps: feeding crude quetiapine hemifumarate in a refining solvent, adding certain amount of fumaric acid, performing backflow pulping, cooling, crystallizing, filtering and drying to obtain a finished quetiapine hemifumarate product. Through adding the certain amount of fumaric acid, the refining yield and the refining efficiency can be respectively and effectively increased and improved. The invention further provides an impurity synthesis method.
