1015242-08-6

Basic information

• Product Name: 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester
• Synonyms: 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester
• CAS NO: 1015242-08-6
• Molecular Formula: C₁₅H₂₄BN₃O₂
• Molecular Weight: 289.18
• Mol File: 1015242-08-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester(1015242-08-6)
• EPA Substance Registry System: 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester(1015242-08-6)

Safety Data

• Hazardous Substances Data: 1015242-08-6(Hazardous Substances Data)

Usage

General Description

The chemical 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester is a boronic acid derivative commonly used in organic synthesis and medicinal chemistry. It contains a boronic acid functional group, which is known for its ability to form stable and selective complexes with certain biological targets, such as enzymes and receptors. This particular compound is a pinacol ester, meaning it contains a pinacol functional group that imparts additional stability and reactivity. The presence of the piperidine and pyrimidine moieties also makes this compound a potentially valuable building block for the synthesis of biologically active molecules, particularly in the development of new pharmaceuticals. Overall, 11 2-(Piperidin-1-yl)pyrimidine- 5-boronic acid pinacol ester is a versatile and important chemical in the fields of medicinal chemistry and drug discovery.

Upstream product

• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 57356-64-6 5-bromo-2-(piperidin-1-yl)pyrimidine 

Downstream Products

• 22539-51-1 5-phenyl-2-N-piperidinylpyrimidine 
• 1279026-33-3 N-methyl-N-{3-[2-(piperidin-1-yl)pyrimidin-5-yl]benzyl}glycinamide 

Relevant articles and documents

Boryl substitution of functionalized aryl-, heteroaryl- and alkenyl halides with silylborane and an alkoxy base: expanded scope and mechanistic studies

A transition-metal-free method has been developed for the boryl substitution of functionalized aryl-, heteroaryl- and alkenyl halides with a silylborane in the presence of an alkali-metal alkoxide. The base-mediated boryl substitution of organohalides with a silylborane was recently reported to provide the corresponding borylated products in good to high yields, and exhibit good functional group compatibility and high tolerance to steric hindrance. In this study, the scope of this transformation has been extended significantly to include a wide variety of functionalized aryl-, heteroaryl- and alkenyl halides. In particular, the boryl substitution of (E)- and (Z)-alkenyl halides proceeded smoothly to afford the corresponding alkenyl boronates in good to high yields with retention of the configuration using modified reaction conditions. The results of the mechanistic studies suggest that this boryl substitution proceeds via a carbanion-mediated mechanism.

PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES

A compound of Formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R1-R6 and A are as defined in the specification.