1017505-71-3

Basic information

• Product Name: N-benzoyl-N'-[1-phenyl-3-(4-nitrophenyl)-4-pyrazolylidene]hydrazine
• Synonyms: N-benzoyl-N'-[1-phenyl-3-(4-nitrophenyl)-4-pyrazolylidene]hydrazine
• CAS NO: 1017505-71-3
• Molecular Weight: 411.42
• Mol File: 1017505-71-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-benzoyl-N'-[1-phenyl-3-(4-nitrophenyl)-4-pyrazolylidene]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-N'-[1-phenyl-3-(4-nitrophenyl)-4-pyrazolylidene]hydrazine(1017505-71-3)
• EPA Substance Registry System: N-benzoyl-N'-[1-phenyl-3-(4-nitrophenyl)-4-pyrazolylidene]hydrazine(1017505-71-3)

Safety Data

• Hazardous Substances Data: 1017505-71-3(Hazardous Substances Data)

Upstream product

• 21487-49-0 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 100-63-0 phenylhydrazine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 77635-72-4 1-(4-nitro-phenyl)-ethanone-phenylhydrazone 

Downstream Products

• 1188421-65-9 C₂₅H₁₉N₅O₄ 
• 1417201-03-6 C₄₆H₃₂N₁₀O₆Pb 
• 1417201-06-9 C₄₆H₃₂FeN₁₀O₆ 
• 1246443-89-9 2-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1, 3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity

A novel series of 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4- oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent anti-inflammatory activity. Among the compounds tested, 9g (2-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazole) was found to be the most potent inhibitor of COX-2 with IC of 0.31 μM showing promising degree of anti-inflammatory activity in the carrageenan-induced rat paw edema model with ED of 74.3 mg/kg. The lead compound 9g further showed suppression of acetic acid-induced writhes comparable to that of aspirin and gastro-sparing profile superior to the aspirin. Molecular docking analysis displayed higher binding affinity of ligands towards COX-2 than COX-1.

Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents

A series of novel 2,5-disubstituted 1,3,4-oxadiazoles 4 have been conveniently synthesized by oxidative cyclization of pyrazolylaldehyde N-acylhydrazones 3 promoted by iodobenzene diacetate under mild conditions (11 examples, up to 92% isolated yields). All the eleven compounds were tested in vitro for their antibacterial activity against Gram-positive bacteria namely, Staphylococcus aureus, Bacillus subtilis and two Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their inhibitory action against two strains of fungus. A series of novel 2,5-disubstituted 1,3,4-oxadiazoles 4 have been conveniently synthesized by oxidative cyclization of pyrazolylaldehyde N-acylhydrazones 3 promoted by iodobenzene diacetate under mild conditions (11 examples, up to 92% isolated yields).