101893-71-4Relevant articles and documents
Method for alpha-position methylation of aryl benzyl sulfone compound
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Paragraph 0045-0048; 0050, (2020/11/23)
The invention discloses a method for alpha-position methylation of an aryl benzyl sulfone compound. The method comprises the following steps: sequentially adding the aryl benzyl sulfone compound, methanol, a metal precursor M, a ligand L, an alkaline substance and a solvent into a reactor, carrying out heating to 110-150 DEG C under the protection of nitrogen, conducting reacting for 20-30 hours,performing cooling to room temperature, conducting concentrating under reduced pressure, recovering the solvent and redundant methanol, and carrying out column chromatographic separation on residues to obtain the alpha-methylated aryl sulfone compound as shown in a formula (I). The method provided by the invention has the characteristics of easily available raw materials, simple operation, high chemical selectivity and regioselectivity and the like, meets the requirements of green chemistry, and has great implementation value and social and economic benefits.