10200-70-1

Basic information

• Product Name: Oxazole, 4,5-dihydro-2-(4-methylphenyl)-
• CAS NO: 10200-70-1
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 10200-70-1.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: Oxazole, 4,5-dihydro-2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4,5-dihydro-2-(4-methylphenyl)-(10200-70-1)
• EPA Substance Registry System: Oxazole, 4,5-dihydro-2-(4-methylphenyl)-(10200-70-1)

Safety Data

• Hazardous Substances Data: 10200-70-1(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-43-5 ethanolamine 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 99-94-5 p-Toluic acid 
• 827-71-4 4-methyl-benzimidic acid ethyl ester 
• 104-85-8 para-methylbenzonitrile 
• 107-06-2 1,2-dichloro-ethane 
• 619-55-6 para-methylbenzamide 
• 107-07-3 2-chloro-ethanol 
• 124-63-0 methanesulfonyl chloride 
• 42469-26-1 N-(2-hydroxyethyl)-4-methylbenzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 148201-87-0 2-p-tolyl-oxazolidine 
• 36615-72-2 phenacylsulfonylacetic acid methyl ester 

Downstream Products

• 62882-04-6 2-(p-tolyl)oxazole 
• 1119512-96-7 bis-(2-[p-tolyl]-2-oxazoline-κ1N) zinc(II) chloride 
• 1119513-03-9 bis-(2-[p-tolyl]-2-oxazoline-κ1N) zinc(II) bromide 
• 104-87-0 4-methyl-benzaldehyde 

Relevant articles and documents

A convenient synthesis of 2-oxazolines and 2-benoxazoles with PPh3-DDQ as the dehydrating reagent

2-Oxazolines and 2-benoxazoles were synthesized in high yields from acylamino alcohols and acylaminophenols, respectively, with triphenylphosphine- 2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DDQ) as the dehydrating and activating reagent. The synthesis was accomplished under neutral conditions.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.

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A convenient synthesis of oxazolines and imidazolines from aromatic aldehydes with pyridinium hydrobromide perbromide in water

Various 2-oxazolines were prepared from aromatic aldehydes and 2-aminoethanol with pyridinium hydrobromide perbromide in water at room temperature. 2-Imidazolines were also obtained in good yields from aromatic aldehydes and ethylenediamine under the same reaction conditions. Georg Thieme Verlag Stuttgart.

A facile synthesis of 2-oxazolines using a PPh3-DDQ system

A facile and efficient synthesis of 2-oxazolines from N-(2-hydroxyethyl)amides using a triphenylphosphine-2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DQQ) system is described. The reaction proceeds under neutral and mild conditions, and excellent yields are obtained.

Oxazolinyl-Assisted Ru(II)-Catalyzed C-H Allylation with Allyl Alcohols and Synthesis of 4-Methyleneisochroman-1-ones

We report herein a ruthenium-catalyzed, oxazoline-directed strategy for C-H allylation of aryl oxazolines using allylic alcohols as the coupling partner. The present transformation unravels the unusual reactivity of allylic alcohols in the synthesis of 4-

Mild, Selective Ru-Catalyzed Deuteration Using D2O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2(PPh3)3] and D2O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.