1023971-15-4Relevant articles and documents
Synthesis method of fudosteine
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Paragraph 0020-0024, (2020/04/06)
The invention relates to a synthesis method of fudosteine, and belongs to the field of biomedicine industry. According to the synthesis method, L-cysteine and acrolein are taken as the raw materials to carry out Michael addition reactions, then sodium borohydride is added to carry out reduction reactions, fudosteine is synthesized by a one-pot method, and finally fudosteine is re-crystallized to obtain high purity fudosteine. The reaction conditions of the preparation method are mild and controllable. The product yield is 95%, and the liquid phase purity is 99.8%.
Preparation method of high-purity fudosteine
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Paragraph 0028-0030, (2018/10/19)
The invention discloses a preparation method of high-purity fudosteine, and belongs to the technical field of synthesis of pharmaceutical compounds. The preparation method is characterized in that with 3-halogenated propyl acetate or 3-halogenated propyl propionate and L-cysteine as starting materials, a fudosteine crude product is prepared through a reaction in an aqueous alkali solution, and high-purity fudosteine is obtained by refining the fudosteine crude product. The preparation method has the advantages that the reaction conditions are mild, the reaction process is simple, the yield ishigh, the cost is low, the requirement that the content of unknown impurities is lower than 0.1% can be met, and the preparation method is suitable for industrial application.
Method for preparing high-purity Fudosteine
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Paragraph 0031, (2018/03/01)
The invention provides a preparation method of a novel antitussive phlegm-eliminating drug high-purity fudosteine, wherein the preparation method includes the steps: (1) synthesizing an intermediate 3-bromo-1-propanol; (2) carrying out a reaction of cysteine hydrochloride with 3-bromo-1-propanol to obtain a crude product; and (3) carrying out crystallization refining on the obtained crude product to obtain the high-purity fudosteine. The domestic cheap easily-available raw materials of cysteine hydrochloride, hydrobromic acid and 1,3-propylene glycol materials are utilized, monitoring of a gas chromatograph, a liquid chromatograph and a refractometer is used for tracking a catalytic reaction process and a reaction terminal point. The preparation method has the advantages of less reaction steps, high selectivity, low pollution, low cost and stable quality, and is suitable for industrialized production.