103128-76-3 Usage
Description
(+)-Chloromethyl menthyl ether is a clear colorless liquid that serves as a versatile chemical intermediate and reagent in various chemical reactions and processes.
Uses
Used in Chemical Synthesis:
(+)-Chloromethyl menthyl ether is used as a starting material for the synthesis of 1-methyl-3-(+)-methylmenthoxide imidazolium chloride, which is a key intermediate for the preparation of Ag(I) N-heterocyclic carbene. This carbene is applicable as a catalyst in the diboration of alkenes, a significant reaction in organic chemistry for the formation of vicinal diols.
Used in Pharmaceutical Industry:
(+)-Chloromethyl menthyl ether serves as a substrate in the synthesis of commercially important O-substituted α-methoxymethylketones. These compounds are valuable in the development of pharmaceuticals and other bioactive molecules due to their unique structural features and potential for further functionalization.
Used in Analytical Chemistry:
(+)-Chloromethyl menthyl ether is utilized to determine the enantiomeric excess (ee) of an iron chiral auxiliary named [Fe(CO)(η;5-C2H5)(PPh3)COCH3]. This application is crucial in the field of asymmetric catalysis and enantioselective synthesis, where the ability to accurately measure ee is essential for assessing the success of a reaction and the quality of the resulting chiral products.
Check Digit Verification of cas no
The CAS Registry Mumber 103128-76-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,1,2 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 103128-76:
(8*1)+(7*0)+(6*3)+(5*1)+(4*2)+(3*8)+(2*7)+(1*6)=83
83 % 10 = 3
So 103128-76-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H21ClO/c1-8(2)10-5-4-9(3)6-11(10)13-7-12/h8-11H,4-7H2,1-3H3/t9-,10+,11-/m0/s1
103128-76-3Relevant articles and documents
Supramolecular interaction of non-racemic benzimidazolium based ion pairs with chiral substrates
Mumtaz, Salma,Cano, Israel,Mumtaz, Nargis,Abbas, Ahmed,Dupont, Jairton,Gondal, Humaira Yasmeen
, p. 20821 - 20826 (2018/08/28)
A series of novel benzimidazolium-based non-racemic ionic liquids (ILs) was synthesized from low-cost chiral terpenoid alcohols and fully characterized by the use of a wide variety of techniques, such as DSC, ESI-MS, ATR FT-IR, polarimetry as well as 1H and 13C NMR spectroscopy. The ILs were investigated as chiral shift agents for the chiral recognition of racemic mixtures of Mosher's acid potassium salt by 19F NMR spectroscopy, leading to high splitting values of the CF3 signal. Supramolecular interactions between salt and H-C2 of chiral benzimidazolium cation are responsible for the chiral recognition, as was demonstrated by experimental evidences. Indeed, the enantiomeric excess value of enantioenriched substrates depends mainly on the strength of the contact ion pairs.