10341-88-5

Basic information

• Product Name: 3-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 3-Phenyl-2-thiophenecarboxylic Acid
• CAS NO: 10341-88-5
• Molecular Formula: C₁₁H₈O₂S
• Molecular Weight: 204.24
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 10341-88-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 315.5°Cat760mmHg
• Flash Point: 144.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 3-PHENYLTHIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYLTHIOPHENE-2-CARBOXYLIC ACID(10341-88-5)
• EPA Substance Registry System: 3-PHENYLTHIOPHENE-2-CARBOXYLIC ACID(10341-88-5)

Safety Data

• Hazardous Substances Data: 10341-88-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the preparation of PARP inhibitors.

InChI:InChI=1/C11H8O2S/c12-11(13)10-9(6-7-14-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 26170-85-4 3-Phenyl-2-thiophenecarboxaldehyde 
• 21676-89-1 methyl 3-phenylthiophene-2-carboxylate 
• 26137-08-6 methyl 3-bromothiophene-2-carboxylate 
• 527-72-0 2-thiophenylcarboxylic acid 
• 591-50-4 iodobenzene 
• 124-38-9 carbon dioxide 
• 2404-87-7 3-phenylthiophene 
• 7311-64-0 3-bromothiophene-2-carboxylic acid 
• 98-80-6 phenylboronic acid 
• 62353-77-9 3-iodothiophene-2-carboxylic acid methyl ester 
• 930-96-1 3-bromo-2-thiophenecarboxaldehyde 
• 4347-31-3 2-formylthiophene-3-boronic acid 
• 108-86-1 bromobenzene 

Downstream Products

• 873581-61-4 (3-phenyl-thiophen-2-yl)-carbamic acid tert-butyl ester 
• 1047672-37-6 1-azabicyclo[2.2.2]oct-4-yl (3-phenyl-2-thienyl)carbamate 
• 21676-89-1 methyl 3-phenylthiophene-2-carboxylate 
• 1579940-00-3 2-(3-phenyl-thiophen-2-ylcarbamoyl)-cyclopent-1-enecarboxylic acid 
• 1293280-54-2 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylthiophen-2-yl)carbonyl]octahydropyrrolo[3 ,4-c]pyrrole 
• 420849-22-5 TIQ-A 

Relevant articles and documents

Towards new neuroprotective agents: Design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors

An excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme able to catalyze the transfer of ADP-ribose from NAD to acceptor proteins, is involved in the progression of neuronal damage after brain insult. Potent and selective PARP-

Redox-Neutral Photocatalytic C?H Carboxylation of Arenes and Styrenes with CO2

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Ruthenium-Catalyzed C-H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides

Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C-H bond.

Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature

Silver-catalyzed C(sp2)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.