1035374-46-9

Basic information

• Product Name: 4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile
• Synonyms: 4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile
• CAS NO: 1035374-46-9
• Molecular Weight: 292.381
• Mol File: 1035374-46-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile(1035374-46-9)
• EPA Substance Registry System: 4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile(1035374-46-9)

Safety Data

• Hazardous Substances Data: 1035374-46-9(Hazardous Substances Data)

Upstream product

• 1035374-45-8 4-((2S)-4-((1R)-1-phenylethyl)morpholin-2-yl)benzaldehyde 
• 879205-74-0 (2S)-2-(4-bromophenyl)-4-[(1R)-1-phenylethyl]morpholine 

Downstream Products

• 1035374-47-0 4-((2S)-morpholin-2-yl)benzonitrile hydrochloride 
• 1245652-72-5 N'-hydroxy-4-((S)-4-((R)-1-phenylethyl)morpholine-2-yl)benzamidine 

Relevant articles and documents

Practical and scalable synthesis of a benzonitrile derivative via palladium-catalyzed cyanation with potassium ferrocyanide

A practical and reproducible synthetic method for the preparation of a benzonitrile derivative (1) from an aryl bromide (2) via Pd-catalyzed cyanation was established with dimethylacetamide (DMAc)-toluene as a mixed solvent. Optimization was examined by a design of experiments (DoE) technique to enhance reaction conversion and reduce the dimeric impurity 3, and desired benzonitrile derivative 1 was successfully obtained in high yields with excellent quality control on a 117 kg scale.

6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g.