103660-35-1Relevant articles and documents
Synthesis of a benzo[b]-1,5-naphthyridine derivative as a potential constrained NK1 receptor antagonist
Viti, Giovanni,Giannotti, Danilo,Nannicini, Rossano,Balacco, Giuseppe,Pestellini, Vittorio
, p. 5939 - 5942 (2007/10/02)
A short synthesis of a cyclic constrained analogue 1 of the potent Substance P antagonist (±) CP-96345 is described. The key feature is the formation of the benzo[b]-1,5-naphthyridine system at the very last step of the synthesis through an intramolecular arylation of an amine promoted by a strong base. If the tricyclic system was synthesized first, 2-methoxy benzylation of both the nitrogen atoms occurred.
SYNTHESIS, STRUCTURE, AND PROPERTIES OF PYRAZOLOQUINUCLIDINE DERIVATIVES
Turchin, K. F.,Yanina, A. D.,Filipenko, T. Ya.,Mikhlina, E. E.,Sheinker, Yu. N.,Yakhtonov, L. N.
, p. 1039 - 1048 (2007/10/02)
It was shown by means of 1H and 13C NMR spectroscopy that the reaction of 2-arylmethylene-3-oxoquinuclidines with hydrazine hydrate gives 4a-hydroxy-7-aryl-4a,5,7,7a-tetrahydropyrazoloquinuclidines, which are stable in the crystalline state but undergo dehydration to the corresponding 7-aryl-6H-7,7a-dihydropyrazoloquinuclidines in solutions.The latter undergo cleavage to the 3-(4-piperidyl)-5-arylpyrazoles when they are heated in an alkaline medium.
