103755-53-9

Basic information

• Product Name: 2-(4-methylphenyl)-2H-[1,2,3]-triazole
• Synonyms: 2-(4-methylphenyl)-2H-[1,2,3]-triazole
• CAS NO: 103755-53-9
• Molecular Weight: 159.191
• Mol File: 103755-53-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-methylphenyl)-2H-[1,2,3]-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-2H-[1,2,3]-triazole(103755-53-9)
• EPA Substance Registry System: 2-(4-methylphenyl)-2H-[1,2,3]-triazole(103755-53-9)

Safety Data

• Hazardous Substances Data: 103755-53-9(Hazardous Substances Data)

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 539-44-6 N-4-methylphenylhydrazine 
• 79762-67-7 glyoxal-bis-p-tolylhydrazone 
• 288-36-8 1 ,2,3-Triazole 
• 106-38-7 para-bromotoluene 

Downstream Products

• 956317-36-5 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid 
• 1616057-68-1 2-(2-(cyclopentyloxy)-4-methylphenyl)-2H-1,2,3-triazole 
• 1171114-58-1 C₁₆H₂₀N₄O 

Relevant articles and documents

Synthesis of 2-Substituted 1,2,3-Triazoles via an Intramolecular N–N Bond Formation

An efficient synthesis of 2-aryl 1,2,3-triazoles based on an intramolecular N–N bond formation is described. Selective activation of bis-hydrazone at the dimethylamino hydrazone group with MeI forms a mono-hydrazonium species. Treatment of the hydrazonium

PREPARATION OF A BENZOIC ACID DERIVATIVE AND ITS USE FOR THE PREPARATION OF SUVOREXANT

The present invention relates to a process for the preparation of a compound of formula (1) wherein the process is based on the use of an organolithium reagent and wherein Ra, Rb, Rc and Rd are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl, heterocycloalkyl, halogen, carbonyl, alkoxy, hydroxyl, -NR6R7, -SR and -NO2, wherein R6 and R7 are, independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein E is an electrophilic group. The present invention further relates as to a compound obtained or obtainable by said method and to a compound of formula (1) as such. Further, the present invention relates to use of the compound of formula (1) for the preparation of Suvorexant.

Palladium-Catalyzed 2H-1,2,3-Triazole-Directed Oxidative Alkoxylation of Arenes with Alcohols

A palladium catalyzed ortho-alkoxylation of aryl C-H bond was accomplished with primary and secondary alcohols as alkoxylation reagents and with triazole as new directing group. This transformation has a good functional group tolerance and is not sensitive to moisture and air. A palladium catalyzed ortho-alkoxylation of aryl C-H bond with alcohols was described. Trizaole was used as new directing group. A series of functional groups could be tolerated and the reaction is not sensitive to moisture and air.