103791-54-4Relevant articles and documents
Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
Florence, Gordon J.,Fraser, Andrew L.,Gould, Eoin R.,King, Elizabeth F. B.,Menzies, Stefanie K.,Morris, Joanne C.,Tulloch, Lindsay B.,Smith, Terry K.
, p. 2548 - 2556 (2014)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are deta
Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
Florence, Gordon J.,Fraser, Andrew L.,Gould, Eoin R.,King, Elizabeth F. B.,Menzies, Stefanie K.,Morris, Joanne C.,Tulloch, Lindsay B.,Smith, Terry K.
supporting information, p. 2548 - 2556 (2015/08/24)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are deta
Total synthesis of (-)-exiguolide
Cook, Cyril,Guinchara, Xavier,Liron, Frederic,Roulland, Emmanuel
supporting information; experimental part, p. 744 - 747 (2011/03/17)
The first total synthesis of the naturally occurring enantiomer of exiguolide ((-)-1) has been completed. This very convergent synthesis features the following as main steps: (I) a Trost's ruthenium-catalyzed ene-yne cross-coupling reaction (this complex transformation allows the challenging control of the C5-C28 double bond geometry along with the stereoselective construction of the tetrahydropyran ring A) and (II) a very efficient one-pot, two-step stereoselective conjugated allyllc alcohol substitution that allowed the control of the C15 stereogenic center.
