1038432-24-4 Usage
Description
(±)-methyl 2-[(tert-butyldimethylsilyl)oxy](3-chlorophenyl)methylprop-2-enoate is a chemical compound with the molecular formula C21H33ClO3Si. It is a derivative of prop-2-enoic acid and contains a tert-butyldimethylsilyl group, a chlorophenyl group, and a methyl ester group. (±)-methyl 2-[(tert-butyldimethylsilyl)oxy](3-chlorophenyl)methylprop-2-enoate is likely to have uses in organic synthesis and pharmaceutical research due to its unique structure and potential reactivity. It may also be used as a building block in the synthesis of more complex organic molecules. The specific properties and potential applications of this compound may vary based on its stereochemistry and other factors.
Uses
Used in Organic Synthesis:
(±)-methyl 2-[(tert-butyldimethylsilyl)oxy](3-chlorophenyl)methylprop-2-enoate is used as a building block for the synthesis of more complex organic molecules. Its unique structure and potential reactivity make it a valuable component in the creation of new compounds with various applications.
Used in Pharmaceutical Research:
(±)-methyl 2-[(tert-butyldimethylsilyl)oxy](3-chlorophenyl)methylprop-2-enoate is used as a starting material or intermediate in the development of new pharmaceuticals. Its unique functional groups and structural features can be exploited to design and synthesize novel drug candidates with potential therapeutic benefits.
Used in Chemical Industry:
(±)-methyl 2-[(tert-butyldimethylsilyl)oxy](3-chlorophenyl)methylprop-2-enoate is used as a specialty chemical in various chemical processes. Its specific properties and reactivity can be harnessed to improve the efficiency and selectivity of chemical reactions, leading to the production of high-quality products.
Check Digit Verification of cas no
The CAS Registry Mumber 1038432-24-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,8,4,3 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1038432-24:
(9*1)+(8*0)+(7*3)+(6*8)+(5*4)+(4*3)+(3*2)+(2*2)+(1*4)=124
124 % 10 = 4
So 1038432-24-4 is a valid CAS Registry Number.
1038432-24-4Relevant articles and documents
A versatile approach to noncoded β-hydroxy-α-amino esters and α-amino acids/esters from morita-baylis-hillman adducts
Ullah, Hamid,Ferreira, Andr V.,Bendassolli, Jos A.,Rodrigues, Manoel T.,Formiga, Andr Luiz B.,Coelho, Fernando
, p. 113 - 123 (2015/02/02)
A simple and straightforward approach to the diastereoselective synthesis of noncoded β-hydroxy-α-amino esters from Morita-Baylis-Hillman (MBH) adducts is described. The strategy is based on a one-pot sequence involving an oxidative cleavage of the double bond of silylated Morita-Baylis-Hillman adducts, followed by the reaction with hydroxylamine hydrochloride/pyridine to form oximes. The stereoselective reduction of the oximes with the mixture MoCl5·nH2O/NaBH3CN led to the corresponding anti-β-hydroxy-α-amino esters in four steps in good overall yield and with diastereoselectivity higher than 95%. A slight modification of the synthetic approach has allowed for the racemic synthesis of a set of noncoded α-amino esters/acids and DOPA
Diastereoselective approach to substituted oxazolidinones from Morita-Baylis-Hillman adducts
Rezende, Patricia,Paioti, Paulo H. S.,Coelho, Fernando
experimental part, p. 227 - 242 (2011/03/19)
We disclose herein a new strategy for the diastereoselective preparation of 4- and 4,5-substituted oxazolidinones from Morita-Baylis-Hillman adducts. The strategy is based on an intramolecular cyclization involving a nucleophilic attack of an alkoxide ion
Acyloins from Morita-Baylis-Hillman adducts: an alternative approach to the racemic total synthesis of bupropion
Amarante, Giovanni W.,Rezende, Patrícia,Cavallaro, Mayra,Coelho, Fernando
, p. 3744 - 3748 (2008/09/21)
In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (α-hydroxyketones) from Morita-Baylis-Hillman adducts, based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic usefulness of this strategy, total synthesis of (±)-bupropion, a dopamine, and nor-epinefrine reuptake inhibitor has been accomplished in eight steps with an overall yield of 25%.
