104143-48-8Relevant articles and documents
Preparation and antiparasitic activity of new imidazoles bearing dioxane or hexahydropyrimidine moiety
Vanelle,Maldonado,Crozet,Senouki,Delmas,Gasquet,Timon-David
, p. 709 - 714 (2007/10/02)
5-Nitro-1,3-dioxane and 5-nitrohexahydropyrimidine salts are found to be suitable nucleophiles for S(RN)1 reactions. From C-alkylation products, base-promoted nitrous acid elimination and acid-catalyzed cleavage of the resulting acetals afford new compounds. Only the imidazole derivatives exhibit significant amoebicide and trichomonacide activities. Structure-activity relationships are discussed.