10417-63-7

Basic information

• Product Name: 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione
• Synonyms: 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione;16α-Methyl Prednisolone;(11beta,16alpha)-11,17,21-Trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione;16alpha-Methylprednisolone
• CAS NO: 10417-63-7
• Molecular Formula: C₂₂H₃₀O₅
• Molecular Weight: 374.4706
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 10417-63-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 571.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Dioxane (Slightly), DMSO (Sparingly), Methanol (Slightly)
• PKA: 12.48±0.70(Predicted)
• CAS DataBase Reference: 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione(10417-63-7)
• EPA Substance Registry System: 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione(10417-63-7)

Safety Data

• Hazardous Substances Data: 10417-63-7(Hazardous Substances Data)

Usage

Description

11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione, also known as 16α-Methylprednisolone, is a synthetic corticosteroid derived from the natural hormone prednisolone. It is characterized by the presence of a methyl group at the 16α position, which enhances its anti-inflammatory properties. This modification results in increased potency and duration of action compared to its parent compound, prednisolone.

Uses

Used in Pharmaceutical Industry:
11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione is used as an anti-inflammatory agent for the treatment of various inflammatory conditions, such as rheumatoid arthritis, systemic lupus erythematosus, and asthma. Its potent anti-inflammatory action helps to reduce inflammation, swelling, and pain associated with these conditions.
Used in Medical Treatments:
In the medical field, 11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione is used as an immunosuppressive agent to prevent organ transplant rejection and to treat autoimmune diseases. Its ability to suppress the immune system makes it a valuable tool in managing conditions where the immune system is overactive or attacking healthy tissues.
Used in Dermatology:
11beta,17alpha,21-Trihydroxy-16alpha-Methyl-1,4-pregnadiene-3,20-dione is also used in dermatology for the treatment of various skin conditions, such as eczema, psoriasis, and allergic reactions. Its anti-inflammatory and immunosuppressive properties help to reduce skin inflammation and itching, providing relief to patients suffering from these conditions.

Downstream Products

• 71868-53-6 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate 
• 10106-41-9 17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate 

Relevant articles and documents

Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid

This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.