104408-23-3

Basic information

• Product Name: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: 3,5-dichloro-2-hydrazinylpyridine;Pyridine,3,5-dichloro-2-hydrazinyl-
• CAS NO: 104408-23-3
• Molecular Formula: C₅H₅Cl₂N₃
• Molecular Weight: 178.02
• Mol File: 104408-23-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(104408-23-3)
• EPA Substance Registry System: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(104408-23-3)

Safety Data

• Hazardous Substances Data: 104408-23-3(Hazardous Substances Data)

Usage

Description

(3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE is an organic compound with the molecular formula C5H5Cl2N3. It is characterized by the presence of a pyridine ring with two chlorine atoms at the 3rd and 5th positions, and a hydrazine group attached to the 2nd position. (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE is known for its reactivity and potential applications in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
(3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE is used as a reactant for the synthesis of (1S,3R)-N-[1-(3-chloropyridin-2-yl)-5-(5-fluoro-6-methylpyridin-3-yl)-4-methyl-1H-pyrazol-3-yl]methyl-3-fluorocyclopentanamine. This synthesized compound is a potential antagonist of the opioid receptor-like 1 (ORL1), which may have therapeutic applications in the treatment of pain and addiction.
The compound (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE plays a crucial role in the development of novel pharmaceuticals targeting the ORL1 receptor. By acting as an antagonist, the synthesized compound may help in modulating the pain response and potentially reduce the risk of addiction associated with traditional opioid medications. This makes it a valuable compound in the ongoing search for more effective and safer pain management options.

Upstream product

• 16063-70-0 2,3,5-trichloropyridine 

Downstream Products

• 334685-44-8 N-(3,5-Dichloro-pyridin-2-yl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 354531-27-4 N-(3,5-Dichloro-pyridin-2-yl)-N'-[1-phenyl-meth-(E)-ylidene]-hydrazine 
• 939437-68-0 (5-bromo-2-hydroxyphenyl)-[1-(3,5-dichloropyridin-2-yl)-1H-pyrazol-4-yl]methanone 

Relevant articles and documents

Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4-Chlorine Substituted N-Pyridylpyrazole

To search for potent insecticides targeting at ryanodine receptors (RyRs), a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized. Their insecticidal activities were evaluated and the preliminary structure-activity relationships (SARs) were discussed. The insecticidal results showed that some of the compounds (8a—8h, 8m, 8n) exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L–1, and compound 8m possessed 60% insecticidal activity at 0.5 mg·L–1. For diamondback moth, 8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. The calcium imaging technique experiment results suggested that compound 8m could increase the intracellular [Ca2+]i. With the neurons preincubated experiment, the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of oriental armyworm. The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.