105016-65-7 Usage
Description
Etoposide 3',4'-Quinone is a dark brown solid that serves as a precursor to the semiquinone free radical of Etoposide. It is a significant compound in the field of pharmaceuticals due to its potential role in inactivating φX174 DNA.
Uses
Used in Pharmaceutical Industry:
Etoposide 3',4'-Quinone is used as a precursor for the semiquinone free radical of Etoposide, which is crucial for its pharmaceutical applications. Its ability to inactivate φX174 DNA makes it a valuable compound in the development of drugs targeting specific genetic material.
Additionally, Etoposide 3',4'-Quinone may be used in the development of anticancer drugs, as its precursor role in the formation of the semiquinone free radical of Etoposide could potentially contribute to the inhibition of tumor growth and progression. However, further research and development would be necessary to explore this application fully.
Check Digit Verification of cas no
The CAS Registry Mumber 105016-65-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,0,1 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 105016-65:
(8*1)+(7*0)+(6*5)+(5*0)+(4*1)+(3*6)+(2*6)+(1*5)=77
77 % 10 = 7
So 105016-65-7 is a valid CAS Registry Number.
105016-65-7Relevant articles and documents
Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry
Pang, Shaokun,Zheng, Naiyu,Felix, Carolyn A.,Scavuzzo, Jennifer,Boston, Ray,Blair, Ian A.
, p. 771 - 781 (2001)
The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication. The genotype of cytochrome P450 3A4 (CYP3A4), which converts etoposide to its catechol metabolite, influences the
Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells
Fan, Yun,Schreiber, Emanuel M.,Giorgianni, Angela,Yalowich, Jack C.,Day, Billy W.
, p. 937 - 943 (2006)
Etoposide is a widely used antineoplastic agent that has provided great success in the treatment of childhood leukemias and other malignancies. Unfortunately, its use is associated with the increased risk of development of secondary acute myelogenous leuk
