105904-51-6Relevant articles and documents
Thiophene and furan appended pyrazoline based fluorescent chemosensors for detection of Al3+ ion
Rangasamy, Manjunath,Palaninathan, Kannan
, p. 177 - 183 (2019)
Thiophene and furan appended pyrazoline receptors R1 and R2 were designed and synthesized for selective detection of Al3+ ion. Their photophysical properties were studied by UV–visible and fluorescence spectra. Surprisingly, both receptors R1 a
Synthesis and evaluation of chalcone derivatives as inhibitors of neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species
Bukhari, Syed N. A.,Tajuddin, Yasmin,Benedict, Vannessa J.,Lam, Kok W.,Jantan, Ibrahim,Jalil, Juriyati,Jasamai, Malina
, p. 198 - 206 (2014/02/14)
Inhibitory effects on neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species (ROS) are among the important targets in developing anti-inflammatory agents and immunosuppressants. Eight series of chalcone derivatives including five newly synthesized series were assessed for their inhibitory effects on chemotaxis, phagocytosis and ROS production in human polymorphonuclear neutrophils (PMNs). Inhibition of PMNs' chemotaxis and phagocytosis abilities were investigated using the Boyden chamber technique and the Phagotest kit, respectively, while ROS production was evaluated using luminol- and lucigenin-based chemiluminescence assay. The new derivatives (4d and 8d), which contain 4-methylaminoethanol functional group were active in all the assays performed. It was also observed that some of the compounds were active in inhibiting chemotaxis while others suppressed phagocytosis and ROS production. The information obtained gave new insight into chalcone derivatives with the potential to be developed as immunomodulators. Chalcone derivatives were synthesised and evaluated for their inhibitory effects on PMNs chemotaxis, phagocytosis and intracellular and extracellular ROS productions. It was observed that phenyl-4-methylaminoethanol and dimethoxy substituents contributed to these effects.
Synthesis and QSAR analysis of chalcone derivatives as nitric oxide inhibitory agent
Lam, Kok Wai,Lajis, Nordin H.,Uddin, Reaz,Ul-Haq, Zaheer,Liew, Choi Yi,Tham, Chau Ling,Israf, Daud A.,Syahida, Ahmad,Rahman, Mohd. Basyaruddin Abdul
, p. 1953 - 1966,14 (2020/07/30)
In this study, thirty-eight chalcone analogs were synthesized and evaluated for nitric oxide (NO) inhibition activity on RAW 264.7 cells. Among these compounds, chalcones bearing furanyl group showed remarkable anti-inflammatory activity. Both compounds 2d and 2j were identified as the most potent NO inhibitor on IFN-γ/LPS-activated RAW 264.7 cells. In order to examine the structure-activity relationship, a 3D QSAR analysis was carried out by comparative molecular field analysis (CoMFA) method on the selected chalcones. Partial least square analysis produced a statistically coherent model with good predictive value, r2 = 0.989 and a good cross validated value, q 2 = 0.583.
