10601-61-3

Basic information

• Product Name: 1-bromo-2-chloro-2-methylpropane
• Synonyms: 1-bromo-2-chloro-2-methylpropane;Einecs 234-222-6
• CAS NO: 10601-61-3
• Molecular Formula: C₄H₈BrCl
• Molecular Weight: 171.46332
• EINECS: 234-222-6
• Mol File: 10601-61-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 129.5°Cat760mmHg
• Flash Point: 45.2°C
• Appearance: /
• Density: 1.438g/cm³
• Vapor Pressure: 12.4mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: 1-bromo-2-chloro-2-methylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-chloro-2-methylpropane(10601-61-3)
• EPA Substance Registry System: 1-bromo-2-chloro-2-methylpropane(10601-61-3)

Safety Data

• Hazardous Substances Data: 10601-61-3(Hazardous Substances Data)

Usage

Description

1-bromo-2-chloro-2-methylpropane, also known as tert-butyl bromochloride, is a colorless, flammable liquid with a strong, unpleasant odor. It is a halogenated hydrocarbon with the molecular formula C4H8BrCl and is commonly used as an alkylating agent in chemical reactions. 1-bromo-2-chloro-2-methylpropane is classified as a hazardous substance that can cause irritation to the skin, eyes, and respiratory system, and may be harmful if ingested or inhaled.

Uses

Used in Organic Synthesis:
1-bromo-2-chloro-2-methylpropane is used as a reagent in organic synthesis for the introduction of the tert-butyl group into organic compounds. Its alkylating properties make it a valuable tool in the synthesis of various organic compounds.
Used in Chemical Reactions:
As an alkylating agent, 1-bromo-2-chloro-2-methylpropane is used in various chemical reactions to transfer the tert-butyl group to other molecules, facilitating the formation of new chemical bonds and the synthesis of desired products.
Used in Pharmaceutical Industry:
1-bromo-2-chloro-2-methylpropane can be used as an intermediate in the synthesis of pharmaceutical compounds, where the introduction of the tert-butyl group may enhance the stability, solubility, or biological activity of the final product.
Used in Agrochemical Industry:
In the agrochemical industry, 1-bromo-2-chloro-2-methylpropane may be used as a precursor in the synthesis of active ingredients for pesticides or herbicides, where the tert-butyl group can improve the performance or selectivity of these compounds.
It is important to handle 1-bromo-2-chloro-2-methylpropane with care due to its hazardous nature, ensuring proper safety measures are in place to minimize the risk of irritation or harm to individuals and the environment.

InChI:InChI=1/C4H8BrCl/c1-4(2,6)3-5/h3H2,1-2H3

Upstream product

• 115-11-7 isobutene 
• 507-20-0 tertiary butyl chloride 
• 594-34-3 1,2-dibromo-2-methyl-propane 

Relevant articles and documents

BiX3 as an efficient and selective reagent for the halogen exchange reaction

Bismuth halides are efficient and selective reagents in the halogen exchange reactions carried out under mild conditions. This rapid, high yield reaction proceeds mainly with retention of configuration.

SELECTIVITIES OF pi - AND sigma -SUCCINIMIDYL RADICALS IN SUBSTITUTION AND ADDITION REACTIONS. APPENDIX: RESPONSE TO WALLING, EL-TALIAWI, AND ZHAO.

A new method for studies of pi -succinimidyl (S// pi ) radicals is described, one that makes possible the study of reactions of this radical with a variety of substrates not accessible by the use of Br//2-NBS. NBS systems containing BrCCl//3 at mole fractions greater than 0. 3 show all the characteristics associated with S// pi behavior, and they function in the presence of olefins which serve as Br//2 scavengers. If CCl//4 is substituted for BrCCl//3, the system is clearly S// sigma . The S// pi behavior is contrasted with S// sigma and Br multiplied by (times) reactivities for H abstractions from a variety of substrates and for additions to tert-butylethylene, isobutylene, and 1,3-butadiene. In early-transition-state systems, for H transfer, the strength of the bond being broken and the strength of the bond being made are not the major factors in determining reactivities. The behavior in late-transition-state systems is influenced by both bond strengths. The S// pi radical shows intermediate behavior. These conclusions are supported by primary deuterium isotope effects for methylene chloride and chlororoform. The Appendix addresses a number of questions raised by the preliminary study of NBS reactions by Walling et al.