1074-99-3Relevant articles and documents
Preparation of nitropyridines by nitration of pyridines with nitric acid
Katritzky, Alan R.,Scriven, Eric F. V.,Majumder, Suman,Akhmedova, Rena G.,Vakulenko, Anatoliy V.,Akhmedov, Novraz G.,Murugan, Ramiah,Abboud, Khalil A.
, p. 538 - 541 (2005)
Preparation of nitropyridines by nitration of pyridines with nitric acid was discussed. Trifluoroacetic anhydride was chilled in an ice bath and the pyridine or substituted pyridines were slowly added and stirred at chilled conditions for 2 h. Relative amounts of the reactants were required for the nitration of pyridine were characterized by 1H and Nuclear magnetic resonance (NMR) spectroscopy and elemental analysis. It was observed that the yields of β-nitropyridines obtained using the standard protocol were generally higher than those obtained using N2O3.
FACTOR XI ACTIVATION INHIBITORS
-
Page/Page column 25; 26, (2021/10/11)
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.
COMPOUNDS HAVING BOTH α7 NICOTINIC AGONIST ACTIVITY AND 5HT3 ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES
-
Page 56 - 57, (2010/02/06)
The invention discloses compounds that are selective α7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases.