1075188-18-9

Basic information

• Product Name: 2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
• Synonyms: 2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
• CAS NO: 1075188-18-9
• Molecular Weight: 568.723
• Mol File: 1075188-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole(1075188-18-9)
• EPA Substance Registry System: 2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole(1075188-18-9)

Safety Data

• Hazardous Substances Data: 1075188-18-9(Hazardous Substances Data)

Upstream product

• 871882-17-6 2,2'-dithiol-5,5'-bis-1H,1'H-benzimidazole 
• 86604-74-2 2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride 

Relevant articles and documents

Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles

A novel symmetrical bis-benzimidazole was designed as DNA minor groove binder. Molecular modeling study showed that it could dock into the minor groove of DNA. Several derivatives were synthesized and confirmed by IR, MS, and 1H NMR. All these novel compounds were screened for cytotoxic activity on SKOV-3, HeLa, and BGC-823 cell lines in vitro. Some compounds showed IC50s in the single-digit micromolar range for cytotoxicity in several tumor cell lines.