1076199-53-5 Usage
Description
N-Boc-(R,S)-Nornicotine, with the chemical name N-(tert-butoxycarbonyl)-(R,S)-3-pyridinamine, is a synthetic compound derived from nicotine. It is characterized by its clear, colorless oil appearance and is utilized in various organic synthesis processes. N-Boc-(R,S)-Nornicotine features a tert-butoxycarbonyl (Boc) protecting group, which is commonly used in organic chemistry to protect amines during reactions. This modification allows for selective reactions to occur at other sites on the molecule, making N-Boc-(R,S)-Nornicotine a versatile intermediate in the synthesis of various pharmaceuticals and other organic compounds.
Uses
Used in Organic Synthesis:
N-Boc-(R,S)-Nornicotine is used as a synthetic intermediate for the preparation of a wide range of organic compounds. Its role in organic synthesis is crucial due to its ability to serve as a precursor to other molecules, facilitating the creation of complex structures and functional groups.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Boc-(R,S)-Nornicotine is utilized as a building block for the development of new drugs and active pharmaceutical ingredients. Its presence in the synthesis process allows for the creation of molecules with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Research and Development:
N-Boc-(R,S)-Nornicotine is also employed in research and development settings, where it can be used to study the effects of nicotine and its derivatives on biological systems. This can lead to a better understanding of nicotine's mechanisms of action and the development of novel therapeutic agents.
Used in Chemical Education:
Furthermore, N-Boc-(R,S)-Nornicotine can be used as a teaching aid in chemical education, illustrating the principles of organic synthesis, protecting group chemistry, and the role of amines in chemical reactions. This helps students grasp complex concepts and understand the practical applications of theoretical knowledge.
Check Digit Verification of cas no
The CAS Registry Mumber 1076199-53-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,6,1,9 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1076199-53:
(9*1)+(8*0)+(7*7)+(6*6)+(5*1)+(4*9)+(3*9)+(2*5)+(1*3)=175
175 % 10 = 5
So 1076199-53-5 is a valid CAS Registry Number.
1076199-53-5Relevant articles and documents
Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)C(sp3) cross-coupling
Abdiaj, Irini,Alcázar, Jesús
, p. 6190 - 6196 (2017)
We report herein the transfer of dual photoredox and nickel catalysis for C(sp2)C(sp3) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and op
N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3)–H Amination of Alkyl Azides
Shing, Ka-Pan,Liu, Yungen,Cao, Bei,Chang, Xiao-Yong,You, Tingjie,Che, Chi-Ming
, p. 11947 - 11951 (2018/09/11)
Metal-catalyzed intramolecular C?H amination of alkyl azides constitutes an appealing approach to alicyclic amines; challenges remain in broadening substrate scope, enhancing regioselectivity, and applying the method to natural product synthesis. Herein we report an iron(III) porphyrin bearing axial N-heterocyclic carbene ligands which catalyzes the intramolecular C(sp3)–H amination of a wide variety of alkyl azides under microwave-assisted and thermal conditions, resulting in selective amination of tertiary, benzylic, allylic, secondary, and primary C?H bonds with up to 95 % yield. 14 out of 17 substrates were cyclized selectively at C4 to give pyrrolidines. The regioselectivity at C4 or C5 could be tuned by modifying the reactivity of the C5–H bond. Mechanistic studies revealed a concerted or a fast re-bound mechanism for the amination reaction. The reaction has been applied to the syntheses of tropane, nicotine, cis-octahydroindole, and leelamine derivatives.
