109163-43-1

Basic information

• Product Name: 4-methoxy-N-(4-methoxybenzyl)benzamide
• Synonyms: 4-methoxy-N-(4-methoxybenzyl)benzamide
• CAS NO: 109163-43-1
• Molecular Weight: 271.316
• Mol File: 109163-43-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-methoxy-N-(4-methoxybenzyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(4-methoxybenzyl)benzamide(109163-43-1)
• EPA Substance Registry System: 4-methoxy-N-(4-methoxybenzyl)benzamide(109163-43-1)

Safety Data

• Hazardous Substances Data: 109163-43-1(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 3424-93-9 4-methoxyphenylacetamide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 25407-31-2 N-(p-methoxyphenacyl)pyridinium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 100-09-4 4-methoxybenzoic acid 
• 696-62-8 para-iodoanisole 
• 696-63-9 4-Methoxybenzenethiol 

Downstream Products

• 62984-77-4 4-methoxyl-N-(4-methoxybenzoyl)benzamide 
• 1297961-54-6 N-ethynyl-4-methoxy-N-(4-methoxybenzyl)benzamide 
• 1297961-63-7 4-methoxy-N-(4-methoxybenzyl)-N-((triisopropylsilyl)ethynyl)benzamide 
• 17061-62-0 N,N-bis(p-methoxybenzyl)amine 
• 148235-14-7 N-(4-hydroxybenzyl)-4-hydroxybenzamide 

Relevant articles and documents

Half-Sandwich Ruthenium Complexes Bearing Hemilabile κ2-(C,S)?Thioether-Functionalized NHC Ligands: Application to Amide Synthesis from Alcohol and Amine

Amide synthesis is one of the most crucial transformations in chemistry and biology. Among various catalytic systems, N-heterocyclic carbene (NHC)-based ruthenium (Ru) catalyst systems have been proven to be active for direct synthesis of amides by sustainable acceptorless dehydrogenative Coupling of primary alcohols with amines. Most often, these catalytic systems usually use monodentate NHC and thus require an additional ligand to obtain high reactivity and selectivity. In this work, a series of cationic Ru(II)(η6-p-cymene) complexes with thioether-functionalized N-heterocyclic carbene ligands (imidazole and benzimidazole-based) have been prepared and fully characterized. These complexes have then been used in the amidation reaction and the most promising one (i. e. 3 c) has been applied on a large range of substrates. High conversions albeit with moderate yields have generally been obtained.

Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst

An efficient method for preparation of secondary amides from primary amides and aldehydes using rhodium on carbon matrix as catalyst was developed. The method does not require any external hydrogen source and carbon monoxide is used as a reducing agent. The most active rhodium catalysts were characterized by BET, TEM and XPS techniques. Unexpectedly, it was found that heterogeneous rhodium on carbon matrix works as precatalyst for homogenous active species due to leaching of rhodium to the solution. Various secondary amides were synthesized and checked for antifungal activity. 4-Methoxy-N-(4-methoxybenzyl)benzamide demonstrated promising activity against Rhizoctonia Solani.

Direct Synthesis of Amides by Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and Ammonia Catalyzed by a Manganese Pincer Complex: Unexpected Crucial Role of Base

Amide synthesis is one of the most important transformations in chemistry and biology. The direct use of ammonia for the incorporation of nitrogen functionalities in organic molecules is an attractive and environmentally benign method. We present here a new synthesis of amides by acceptorless dehydrogenative coupling of benzyl alcohols and ammonia. The reaction is catalyzed by a pincer complex of earth-abundant manganese in the presence of a stoichiometric base, making the overall process economical, efficient, and sustainable. Interesting mechanistic insights based on detailed experimental observations, indicating the crucial role of the base, are provided.