109619-81-0Relevant articles and documents
Highly enantioselective construction of the α-chiral center of amides via iridium-catalyzed hydrogenation of α,β-unsaturated amides
Lu, Wei-Jing,Hou, Xue-Long
supporting information; experimental part, p. 1224 - 1228 (2009/12/06)
The chiral center at the a-position of amides is installed in excellent enantioselectivity via the iridium-catalyzed asymmetric hydrogenation of αβ-unsaturated amides under mild conditions. Even aliphatic amides are suitable substrates. The presence of a
A Simple and Efficient Route to 2-Alkyl-2-alkenoic Acids and 2-Phenyl-2-Alkenoic Acids by the Horner Synthesis. Application to the Steroselective Synthesis of the Pheromone Manicone
Coutrot, Philippe,Ghribi, Abdellaziz
, p. 790 - 792 (2007/10/02)
A general synthesis of α-branched α,β-unsaturated carboxylic acids is described.A Horner reaction of 2-diethoxyphosphorylalkanoic acid dianions (lithium α-lithiocarboxylates) with carbonyl compounds is used.The reaction is applied to the stereoselective synthesis of Manicone.
